Different regulation of PARP1, PARP2, PARP3 and TRPM2 genes expression in acute myeloid leukemia cells.

Paulina Gil-KulikEwa DudzińskaElżbieta Radzikowska-BüchnerJoanna WawerMariusz JojczukAdam NogalskiGenowefa Anna WawerMarcin FeldoWojciech KockiMaria CiochAnna Bogucka-KockaMansur RahnamaJanusz Kocki

Published in: BMC cancer (2020)

Our research suggests that in physiological conditions in the cells of the hematopoietic system there is mutual positive regulation of PARP1, PARP2, PARP3, and TRPM2 genes expression. PARP1, PARP2, and TRPM2 genes at mRNA level deregulate in acute myeloid leukemia cells.

Keyphrases

dna damage
dna repair
induced apoptosis
cell cycle arrest
poor prognosis
genome wide
oxidative stress
cell death
binding protein
gene expression
signaling pathway
dna methylation
pi k akt
cell proliferation
genome wide analysis