Portulaca oleracea L seed extracts counteract diabetic nephropathy through SDF-1/IL10/PPARγ-mediated tuning of keap1/Nrf2 and NF-κB transcription in Sprague Dawley rats.
Wessam Magdi AzizSamia A AhmedSylvia E ShakerDalia B FayedNadia S MetwallyHeba ShawkyPublished in: Diabetology & metabolic syndrome (2024)
These findings highlight the remarkable DN-prophylactic potentials of purslane extracts mediated by neutralizing the hyperglycemia-induced ROS accumulation, and circumventing the downstream inflammatory cascades, surpassing the reference angiotensin receptor blocker; i.e. Losartan.
Keyphrases
- diabetic nephropathy
- oxidative stress
- diabetic rats
- angiotensin ii
- angiotensin converting enzyme
- signaling pathway
- dna damage
- cell death
- high glucose
- insulin resistance
- lps induced
- type diabetes
- dengue virus
- cell proliferation
- pi k akt
- immune response
- metabolic syndrome
- fatty acid
- small molecule
- toll like receptor
- inflammatory response