Serjanic Acid Glycosides from Chenopodium hybridum L. with Good Cytotoxicity and Selectivity Profile against Several Panels of Human Cancer Cell Lines.
Karolina GrabowskaŁukasz PecioAgnieszka GalantyPaweł ŻmudzkiWiesław OleszekIrma PodolakPublished in: Molecules (Basel, Switzerland) (2021)
Two triterpene saponins, including a novel serjanic acid derivative, were isolated from Chenopodium hybridum L. (Amaranthaceae) aerial parts. Their structures were elucidated by a combination of spectroscopic methods (MS, 1D and 2D NMR). Both compounds were evaluated for cytotoxicity and selectivity on skin, prostate, gastrointestinal, thyroid and lung cancer cells. Their effect was dose and time-dependent with varied potency, the highest against prostate PC3 and melanoma WM793, where IC50 was lower than the reference drug doxorubicin. Structure-activity relationship is briefly discussed.
Keyphrases
- prostate cancer
- structure activity relationship
- benign prostatic hyperplasia
- high resolution
- endothelial cells
- mass spectrometry
- papillary thyroid
- magnetic resonance
- molecular docking
- multiple sclerosis
- drug delivery
- ms ms
- squamous cell carcinoma
- emergency department
- pluripotent stem cells
- structural basis
- soft tissue
- solid state
- skin cancer