The BTLA and PD-1 signaling pathways independently regulate the proliferation and cytotoxicity of human peripheral blood γδ T cells.
Hyun J HwangJae J LeeSung H KangJin K SuhEun S ChoiSeongsoo JangSang-Hyun HwangKyung-Nam KohHo J ImNayoung KimPublished in: Immunity, inflammation and disease (2020)
These results suggest that BTLA signaling is crucial in regulating γδ T cell proliferation and function and that the BTLA and PD-1 signaling pathways act independently on the proliferation and cytotoxicity of human peripheral γδ T cells.