Association of ORMDL3 with rhinovirus-induced endoplasmic reticulum stress and type I Interferon responses in human leucocytes.
Y-P LiuV RajamanikhamM BaronS PatelS K MathurE A SchwantesC OberD J JacksonJ E GernR F LemanskeJudith A SmithPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2017)
Multiple lines of evidence support an association between higher ORMDL3 and increased rhinovirus-induced HSPA5 and type I IFN gene expression. These associations with ORMDL3 are cell type specific, with the most significant 17q21 genotype effects on ORMDL3 expression and HSPA5 induction evident in B cells. Together, these findings have implications for how the interaction of increased ORMDL3 and rhinovirus may predispose to asthma.
Keyphrases
- endoplasmic reticulum stress
- gene expression
- high glucose
- endothelial cells
- induced apoptosis
- diabetic rats
- dendritic cells
- poor prognosis
- immune response
- drug induced
- heat shock protein
- chronic obstructive pulmonary disease
- lung function
- air pollution
- signaling pathway
- allergic rhinitis
- long non coding rna
- induced pluripotent stem cells
- stress induced