Pre-irradiation intensive induction and marrow-ablative consolidation chemotherapy in young children with newly diagnosed high-grade brainstem gliomas: report of the "head-start" I and II clinical trials.

Diana S OsorioNeha PatelLingyun JiRichard SpostoJoseph StanekSharon L GardnerJeffrey C AllenAlbert CorneliusGeoffrey B McCowageAmanda TermuhlenIra J DunkelMelanie ComitoJames GarvinJonathan L Finlay

Published in: Journal of neuro-oncology (2018)

Children with high-grade BSG did not benefit from this intensive chemotherapy strategy administered prior to irradiation.

Keyphrases

high grade
newly diagnosed
low grade
clinical trial
locally advanced
young adults
squamous cell carcinoma
randomized controlled trial
chemotherapy induced
rectal cancer
open label
study protocol
phase iii