Effectiveness of Soluble CTLA-4-Fc in the Inhibition of Bone Marrow T-Cell Activation in Context of Indoleamine 2.3-Dioxygenase (IDO) and CD4 + Foxp3 + Treg Induction.

Magdalena Massalska Marzena Ciechomska Ewa Kuca WarnawinTomasz BurakowskiAnna KornatkaAnna Radzikowska Dariusz Pawlak Barbara Muz Adrianna Loniewska-LwowskaAndrzej PaluchaPaweł Małdyk Wlodzimierz Maslinski

Published in: Journal of inflammation research (2022)

This study sheds light on some immunosuppression aspects present or induced in BM. The potential of IDO-mediated pathways were confirmed in the periphery, what may represent the promising candidates for therapeutic strategies in RA.

Keyphrases

bone marrow
randomized controlled trial
mesenchymal stem cells
regulatory t cells
systematic review
rheumatoid arthritis
high glucose
diabetic rats
drug induced
immune response
endothelial cells
risk assessment
ankylosing spondylitis
climate change