Increased SPON1 promotes pancreatic ductal adenocarcinoma progression by enhancing IL-6 trans-signalling.

Yanmiao HuoJian YangJiahao ZhengDapeng XuMinwei YangLingye TaoHongfei YaoXueliang FuJianyu YangDejun LiuRong HuaJunfeng ZhangYongwei SunLi-Peng HuWei Liu

Published in: Cell proliferation (2022)

Our data indicate that SPON1 expression is dramatically increased in PDAC and that SPON1 promotes tumorigenicity by activating the sIL-6R/gp130/STAT3 axis. Collectively, our current work suggests SPON1 may be a potential therapy target for PDAC patient.

Keyphrases

poor prognosis
signaling pathway
cell proliferation
case report
electronic health record
big data
long non coding rna
human health
risk assessment
bone marrow
cell therapy
data analysis