The effect of Nipped-B-like (Nipbl) haploinsufficiency on genome-wide cohesin binding and target gene expression: modeling Cornelia de Lange syndrome.

Daniel A NewkirkYen-Yun ChenRichard ChienWeihua ZengJacob BiesingerEbony FlowersShimako KawauchiRosaysela SantosAnne L CalofArthur D LanderXiaohui XieKyoko Yokomori

Published in: Clinical epigenetics (2017)

Decreased cohesin binding at the gene regions is directly linked to disease-specific expression changes. Taken together, our Nipbl haploinsufficiency model allows us to analyze the dosage effect of cohesin loading on CdLS development.

Keyphrases

genome wide
gene expression
dna methylation
binding protein
copy number
poor prognosis
dna binding
case report
long non coding rna
transcription factor