VEGFR-2 redirected CAR-T cells are functionally impaired by soluble VEGF-A competition for receptor binding.

Evripidis Lanitis Paris KostiCatherine RonetElisabetta CribioliGiorgia RotaAodrenn SpillPatrick ReichenbachVincent ZoeteDenarda Dangaj LanitiGeorge CoukosMelita Irving

Published in: Journal for immunotherapy of cancer (2022)

This study represents the first example of impaired function of a vasculature-targeted CAR by an angiogenic ligand and rationalizes the use of combinatorial therapies that target the tumor vasculature and augment CAR-T cell effector function.

Keyphrases

vascular endothelial growth factor
endothelial cells
dendritic cells
cancer therapy
binding protein
dna binding
transcription factor