Management of acute chest syndrome in patients with sickle cell disease: a systematic review of randomized clinical trials.
Muhammad Rafay Khan NiaziDivya ChukkaloreAbdullah JahangirSyeda SahraKira MacdougallMaryam RehanMarcel OdaimiPublished in: Expert review of hematology (2022)
11 randomized controlled trials were found that evaluated the efficacy of incentive spirometry, positive expiratory pressure device, intravenous dexamethasone, oral vs. intravenous morphine, inhaled nitric oxide, unfractionated heparin, and blood transfusion in the prevention or treatment of ACS. Although there are guidelines for ACS treatment, the available evidence is very limited to delineating the effectiveness of various interventions in ACS management. More high-quality studies and trials with a larger patient population can benefit this area to support the recommendations with stronger evidence.
Keyphrases
- acute coronary syndrome
- sickle cell disease
- nitric oxide
- randomized controlled trial
- high dose
- case report
- low dose
- clinical practice
- liver failure
- venous thromboembolism
- hydrogen peroxide
- intensive care unit
- growth factor
- nitric oxide synthase
- study protocol
- acute respiratory distress syndrome
- smoking cessation
- mechanical ventilation