Hormone pathway comparison in non-idiopathic and idiopathic progressive subglottic stenosis.

Ivana FizWiebke AntonopoulosJan-Constantin KölmelKarina RüllerFrancesco FizCesare PiazzaGiorgio PerettiChrista FlechtenmacherPeter SchirmacherChristian Sittel

Published in: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (2022)

The IPSS pathogenesis appears to be driven by hormonal mechanisms, in particular, by over-expression of PR. Marginal cells display a reduced hormone receptor density. This finding could be interpreted as a compensatory mechanism. These findings could open up for targeted IPSS treatment.

Keyphrases

induced apoptosis
poor prognosis
multiple sclerosis
cell cycle arrest
cancer therapy
polycystic ovary syndrome
cell death
oxidative stress
binding protein
adipose tissue
combination therapy
insulin resistance
replacement therapy