Pharmacological Effects of Centella asiatica on Skin Diseases: Evidence and Possible Mechanisms.
Kyoung Sik ParkPublished in: Evidence-based complementary and alternative medicine : eCAM (2021)
The medicinal herb Centella asiatica (L.) Urban known as gotu kola has been reported to exhibit a wide range of pharmacological activities. In particular, a significant body of scientific research exists on the therapeutic properties of preparations of C. asiatica or its triterpenes in the treatment of skin diseases. The present study is aimed to provide a comprehensive overview of the beneficial effects of C. asiatica on skin diseases. Peer-reviewed articles on the potent dermatological effects of C. asiatica were acquired from PubMed, Web of Science, Scopus, ScienceDirect, and SciFinder. This review provides an understanding of pharmacological studies which confirm the potent dermatological effects and underlying molecular mechanisms of C. asiatica. This medicinal plant and its triterpenes include asiaticoside, madecassoside, and their aglycones, asiatic acid and madecassic acid. These compounds exert therapeutic effects on dermatological diseases such as acne, burns, atopic dermatitis, and wounds via NF-κB, TGF-β/Smad, MAPK, Wnt/β-catenin, and STAT signaling in in vitro and in vivo studies. However, additional rigorously controlled long-term clinical trials will be necessary to confirm the full potential of C. asiatica as a therapeutic agent.
Keyphrases
- clinical trial
- cell proliferation
- soft tissue
- wound healing
- transforming growth factor
- epithelial mesenchymal transition
- atopic dermatitis
- oxidative stress
- stem cells
- public health
- pi k akt
- randomized controlled trial
- case control
- nuclear factor
- lps induced
- replacement therapy
- combination therapy
- climate change
- toll like receptor