Necroptosis-driving genes RIPK1, RIPK3 and MLKL-p are associated with intratumoral CD3 + and CD8 + T cell density and predict prognosis in hepatocellular carcinoma.

Lorenzo Nicolè Tiziana SanaviaRocco CappellessoValeria MaffeisJun AkibaAkihiko KawaharaYoshiki NaitoClaudia Maria RaduPaolo SimioniDavide SerafinGiuliana CorteseMaria GuidoGiacomo ZanusHirohisa YanoAmbrogio Fassina

Published in: Journal for immunotherapy of cancer (2022)

Our results confirmed the immunogenetic properties of necroptosis (NCP) in human HCC, showing that tumor-infiltrating lymphocytes (TILs) and, specifically, CD8+ T cells accumulate in tumors with higher expression of the necroptosis-related genes. These results suggest the importance of further studies to better assess the specific composition, as well as the functional features of the immune environment associated with a necroptotic signature in order to explore new possible diagnostic and immunotherapeutic scenarios.

Keyphrases

endothelial cells
poor prognosis
climate change
genome wide
peripheral blood
binding protein
gene expression
genome wide identification
transcription factor