Antiviral, Antibacterial, Antifungal, and Cytotoxic Silver(I) BioMOF Assembled from 1,3,5-Triaza-7-Phoshaadamantane and Pyromellitic Acid.
Sabina W JarosJarosław KrólBarbara A BażanówDominik PoradowskiAleksander ChrószczDmytro S NesterovAlexander M KirillovPiotr SmoleńskiPublished in: Molecules (Basel, Switzerland) (2020)
The present study reports the synthesis, characterization, and crystal structure of a novel bioactive metal-organic framework, [Ag4(µ-PTA)2(µ3-PTA)2(µ4-pma)(H2O)2]n·6nH2O (bioMOF 1), which was assembled from silver(I) oxide, 1,3,5-triaza-7-phosphaadamantane (PTA), and pyromellitic acid (H4pma). This product was isolated as a stable microcrystalline solid and characterized by standard methods, including elemental analysis, 1H and 31P{1H} NMR and FTIR spectroscopy, and single crystal X-ray diffraction. The crystal structure of 1 disclosed a very complex ribbon-pillared 3D metal-organic framework driven by three different types of bridging ligands (µ-PTA, µ3-PTA, and µ4-pma4-). Various bioactivity characteristics of bioMOF 1 were investigated, revealing that this compound acts as a potent antimicrobial against pathogenic strains of standard Gram-negative (Escherichia coli, Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacteria, as well as a yeast (Candida albicans). Further, 1 showed significant antiviral activity against human adenovirus 36 (HAdV-36). Finally, bioMOF 1 revealed high cytotoxicity toward an abnormal epithelioid cervix carcinoma (HeLa) cell line with low toxicity toward a normal human dermal fibroblast (NHDF) cell line. This study not only broadens the family of PTA-based coordination polymers but also highlights their promising multifaceted bioactivity.
Keyphrases
- metal organic framework
- candida albicans
- gram negative
- escherichia coli
- biofilm formation
- staphylococcus aureus
- pseudomonas aeruginosa
- endothelial cells
- multidrug resistant
- high resolution
- gold nanoparticles
- magnetic resonance
- oxidative stress
- induced pluripotent stem cells
- drug resistant
- cystic fibrosis
- signaling pathway
- anti inflammatory
- magnetic resonance imaging
- acinetobacter baumannii
- pluripotent stem cells
- cell death
- klebsiella pneumoniae
- room temperature
- atomic force microscopy
- ionic liquid
- adverse drug
- crystal structure