Pooled Population Pharmacokinetic Analysis for Exploring Ciprofloxacin Pharmacokinetic Variability in Intensive Care Patients.

Tingjie GuoAlan AbdullaBirgit C P KochJohan G C van HasseltHenrik EndemanJeroen A SchoutenPaul W G ElbersRoger J M BrüggemannReinier M van Hestnull null

Published in: Clinical pharmacokinetics (2022)

We developed a population PK model of ciprofloxacin in ICU patients using pooled data of individual patients from three studies. A simple ciprofloxacin dose recommendation for the entire ICU population remains challenging owing to the PK differences within ICU patients, hence dose individualization may be needed for the optimization of ciprofloxacin treatment.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
intensive care unit
peritoneal dialysis
randomized controlled trial
clinical trial
study protocol
acute respiratory distress syndrome
data analysis