Structurally diverse oxygen-containing aromatic compounds with anti-inflammatory activity from Aspergillus sp. LY-1-2.
Chu-Qiao WangJinzhi PanShuang-Zhi YuanChao YuanFei-Xiang JiDan FengXiao-Ping PengQian LuoHong-Xiang LouGang LiPublished in: Natural product research (2024)
Three isocoumarins, ascoisocoumarin A ( 1 ), embeurekol ( 2 ), and sclerotinin A ( 3 ), and five biosynthetically related derivatives, ascospinols A-C ( 4 , 6 , and 7 ), and talaflavuols C and B ( 5 and 8 ), together with twelve polyketides or terpenes ( 9 - 20 ) were isolated from the fungus Aspergillus sp. LY-1-2 inhabited in a sample of Cordyceps sp. Most of them belong to the family of oxygen-containing aromatic compounds and compounds 1 , 4 , 6 , and 7 are previously undescribed compounds. Their planar structures were established by a combined spectroscopic analysis of HRESIMS and NMR, and their stereochemistry was determined by 13 C NMR calculations with sorted training set (STS) protocol analysis, and ECD calculations. New compounds 1 and 6 displayed potential anti-inflammatory effects in lipopolysaccharide (LPS)-induced BV2 microglia cells.
Keyphrases
- lps induced
- inflammatory response
- high resolution
- magnetic resonance
- molecular dynamics
- density functional theory
- randomized controlled trial
- induced apoptosis
- lipopolysaccharide induced
- molecular docking
- solid state
- cell proliferation
- spinal cord injury
- neuropathic pain
- mass spectrometry
- signaling pathway
- cell death
- cell wall