Inhibition of Human Malignant Pleural Mesothelioma Growth by Mesenchymal Stromal Cells.
Valentina CocceSilvia La MonicaMara BonelliGiulio AlessandriRoberta AlfieriCostanza Annamaria LagrastaDenise MadedduCaterina FratiLisa FlamminiDaniela LisiniAngela MarciantiEugenio ParatiFrancesca PainoAldo Bruno GianniGiampietro FarronatoAngela FalcoLorenzo SpaggiariFrancesco PetrellaAugusto PessinaPublished in: Cells (2021)
These data demonstrated for the first time that MSCs, both through paracrine and cell-to-cell interaction mechanisms, induced a significant inhibition of human mesothelioma growth. Since the prognosis for MPM patients is poor and the options of care are limited to chemotherapy, MSCs could provide a potential new therapeutic approach for this malignancy.
Keyphrases
- endothelial cells
- mesenchymal stem cells
- single cell
- end stage renal disease
- cell therapy
- newly diagnosed
- healthcare
- high glucose
- induced pluripotent stem cells
- ejection fraction
- chronic kidney disease
- pluripotent stem cells
- bone marrow
- palliative care
- umbilical cord
- stem cells
- machine learning
- risk assessment
- radiation therapy
- diabetic rats
- patient reported
- health insurance
- rectal cancer