Maternal mRNA covid-19 vaccination during pregnancy and delta or omicron infection or hospital admission in infants: test negative design study.

Sarah C J JorgensenAlejandro HernandezDeshayne B FellPeter C AustinRohan D'Souza Astrid GuttmannKevin A BrownSarah A BuchanJonathan B GubbaySharifa Nasreen Kevin L SchwartzMina TadrousKumanan WilsonJeffrey C Kwongnull null

Published in: BMJ (Clinical research ed.) (2023)

Maternal covid-19 vaccination with a second dose during pregnancy was highly effective against delta and moderately effective against omicron infection and hospital admission in infants during the first six months of life. A third vaccine dose bolstered protection against omicron. Effectiveness for two doses was highest with maternal vaccination in the third trimester, and effectiveness decreased in infants beyond eight weeks of age.

Keyphrases

pregnancy outcomes
birth weight
coronavirus disease
sars cov
gestational age
randomized controlled trial
emergency department
systematic review
healthcare
adverse drug
preterm birth
respiratory syndrome coronavirus