High salt diet inhibits the expression of Bmal1 and promotes atrial fibrosis and vulnerability to atrial fibrillation in Dahl salt sensitive rats.
Xiu-Heng WangZhi-Zhu ZhangYun OuZhi-Hong NingJia-Yang YangHong HuangHui-Fang TangZhi-Sheng JiangHeng-Jing HuPublished in: American journal of hypertension (2024)
We demonstrated that a high-salt diet leads to circadian changes in hypertension due to reduction Bmal1 expression, which plays a crucial role in atrial fibrosis and increased susceptibility to AF in SSHT rats.
Keyphrases
- atrial fibrillation
- poor prognosis
- catheter ablation
- left atrial
- oral anticoagulants
- weight loss
- physical activity
- left atrial appendage
- blood pressure
- direct oral anticoagulants
- binding protein
- climate change
- percutaneous coronary intervention
- acute coronary syndrome
- coronary artery disease
- left ventricular
- mitral valve
- venous thromboembolism