Perforation and Fistula of the Gastrointestinal Tract in Patients with Necrotizing Pancreatitis: a Nationwide Prospective Cohort.
Hester C TimmerhuisSven M van DijkRobert A HollemansDevica S UmansChristina J Sperna WeilandMarc G BesselinkStefan A W BouwenseMarco J BrunoPeter van DuijvendijkCasper H J van EijckYama IssaSven MieogI Quintus MolenaarMartijn W J StommelThomas L BollenRogier P VoermansRobert C VerdonkHjalmar C van Santvoortnull nullPublished in: Annals of surgery (2022)
Perforation and fistula of the GI-tract occurred in one out of six patients with necrotizing pancreatitis. Risk factors were high C-reactive protein within 48 hours and early organ-failure. Prior intervention was identified as a risk factor for perforation or fistula of the lower GI-tract. The clinical course was mostly affected by involvement of the lower GI-tract.
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