YARS as an oncogenic protein that promotes gastric cancer progression through activating PI3K-Akt signaling.

Cheng ZhangXiaoting LinQian ZhaoYakun WangFangli JiangCongcong JiYanyan LiJing GaoJian LiLin Shen

Published in: Journal of cancer research and clinical oncology (2020)

By revealing the existence of a YARS-PI3K-Akt signaling axis in gastric cancer, we discovered that tRNA synthetase YARS is a novel tumorigenic factor, characterized by its upregulation in tumor-derived specimens, as well as its functions in promoting gastric cancer progression.

Keyphrases

pi k akt
signaling pathway
cell proliferation
cell cycle arrest
poor prognosis
transcription factor
cell death
small molecule