Determination of Apoptotic Mechanism of Action of Tetrabromobisphenol A and Tetrabromobisphenol S in Human Peripheral Blood Mononuclear Cells: A Comparative Study.

Anna Barańska Bożena Bukowska Jaromir Michałowicz

Published in: Molecules (Basel, Switzerland) (2022)

It was found that TBBPS, and more strongly TBBPA, triggered apoptosis in human PBMCs. Generally, the mitochondrial pathway was involved in the apoptotic action of tested compounds; nevertheless, TBBPS more strongly than TBBPA caused intrinsic pathway activation.

Keyphrases

cell death
endothelial cells
oxidative stress
pluripotent stem cells
anti inflammatory
cell cycle arrest
endoplasmic reticulum stress
cell proliferation
high resolution
solid phase extraction
liquid chromatography
pi k akt