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miR-297 inhibits expression of progesterone receptor and decidualization in eutopic endometria of endometriosis.

Tingting LiuLi XiaoTianjiao PeiBin LuoJing TanYing LongXin HuangYunwei OuyangRong Zhou
Published in: The journal of obstetrics and gynaecology research (2022)
We demonstrated that miR-297 interferes with fertility by repressing the expression of PR and preventing efficient decidualization in eutopic endometria. Further, miR-297 directly contributes to progesterone resistance in minimal or mild cases of endometriosis. Thus, regulation of miR-297 may prove to be a promising therapeutic strategy for endometriosis.
Keyphrases
  • long non coding rna
  • cell proliferation
  • poor prognosis
  • long noncoding rna
  • binding protein
  • estrogen receptor