Single-nuclear transcriptome profiling identifies persistent fibroblast activation in hypertrophic and failing human hearts of patients with longstanding disease.
Badder KattihFelicitas BoecklingMariana ShumliakivskaLukas S TomborTina RasperKatja SchmitzJedrzej HoffmannLuka NicinWesley T AbplanalpDaniel C CarstensMani ArsalanFabian EmrichTomas HolubecThomas WaltherValentina O PuntmannEike NagelDavid JohnAndreas M ZeiherStefanie DimmelerPublished in: Cardiovascular research (2023)
Together, this study identifies persistent fibroblast activation in patients with longstanding heart disease, which might be detected by circulating AEBP1 and therapeutically modulated by its targeted silencing in human cardiac fibroblasts.