Impact of childhood adversity on acute subjective effects of stimulant and opioid drugs: Evidence from placebo-controlled studies in healthy volunteers.
Molly CarlyleHarriet de WitSiri LeknesPublished in: Journal of psychopharmacology (Oxford, England) (2024)
Childhood adversity was not significantly associated with other subjective or heart rate responses to the drugs. Overall, participants with more childhood adversities reported dampened subjective responses to stimulant drugs, but not to buprenorphine. Future studies should examine the generalisability of these relationships, to identify the mechanisms underlying the link between childhood adversity and drug responsiveness.
Keyphrases
- early life
- heart rate
- drug induced
- attention deficit hyperactivity disorder
- heart rate variability
- blood pressure
- childhood cancer
- liver failure
- placebo controlled
- pain management
- randomized controlled trial
- emergency department
- clinical trial
- depressive symptoms
- autism spectrum disorder
- current status
- rectal cancer
- adverse drug
- mechanical ventilation