Effect of Atorvastatin on Knee Cartilage Volume in Patients With Symptomatic Knee Osteoarthritis: Results From a Randomized Placebo-Controlled Trial.

Yuanyuan WangGraeme JonesCatherine L Hill Anita E WlukaAndrew B ForbesAndrew TonkinSultana Monira Hussain Changhai DingFlavia M Cicuttini

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)

Treatment with oral atorvastatin (40 mg once daily), compared to placebo, did not significantly reduce cartilage volume loss over 2 years in patients with symptomatic knee OA. These findings do not support the use of atorvastatin for the treatment of knee OA.

Keyphrases

knee osteoarthritis
total knee arthroplasty
randomized controlled trial
double blind
clinical trial
combination therapy
study protocol
anterior cruciate ligament reconstruction
replacement therapy
phase iii
placebo controlled