Genetic alterations related to endoscopic treatment of colorectal tumors.

Toru KunoYuya TsukuiShinichi TakanoShinya MaekawaTatsuya YamaguchiTakashi YoshidaShoji KobayashiFumihiko IwamotoYasuaki IshidaSatoshi KawakamiKeisuke TanakaYoshimitsu FukasawaMasaru MuraokaMitsuharu FukasawaHiroko ShindoTaisuke InoueYasuhiro NakayamaKunio MochizukiTadashi SatoNobuyuki Enomoto

Published in: JGH open : an open access journal of gastroenterology and hepatology (2019)

Numbers of copy number variations and TP53 and SMAD4 alterations were related to colorectal tumor progression. TP53 alteration rates in adenoma components were high in T1b carcinomas, warranting complete treatment with en bloc resection. Magnifying endoscopic findings might reflect the genetic status of colorectal tumors.

Keyphrases

copy number
genome wide
mitochondrial dna
ultrasound guided
dna methylation
poor prognosis
combination therapy
replacement therapy
drug induced