DNA-PK-Mediated Cytoplasmic DNA Sensing Stimulates Glycolysis to Promote Lung Squamous Cell Carcinoma Malignancy and Chemoresistance.

Hui Wang Yanyang Zhang Yu Tian Wanlin Yang Yan Wang Hui Hou Hanbo Pan Siyu Pei Hongda Zhu Zenan Gu Yanyun Zhang Dongfang Dai Wei Chen Mingyue Zheng Qingquan Luo Yi-Chuan Xiao Jia Huang

Published in: Cancer research (2024)

DNA-PK is a cytoplasmic DNA sensor that activates ZAK/AKT/mTOR signaling and boosts glycolysis to enhance malignancy and chemoresistance of lung squamous cell carcinoma.

Keyphrases

circulating tumor
squamous cell carcinoma
cell free
single molecule
cell proliferation
nucleic acid
signaling pathway
circulating tumor cells
lymph node metastasis