Mingyue Zheng

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2014-2024
Publications (10 Years): 95

Top Venues

Journal of medicinal chemistry

Nature communications

ACS medicinal chemistry letters

Nature immunology

Shanghai Institute of Materia Medica

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Shanghai Institute of Materia Medica Jul 01 2006

China

Professor :: State Key Laboratory of Drug Research

Publications

Xuehui Long, Sulin Zhang, Yuliang Wang, Jingjing Chen, Yanlai Lu, Hui Hou, Bichun Lin, Xutong Li, Chang Shen, Ruirui Yang, Huamin Zhu, Rongrong Cui, Duanhua Cao, Geng Chen, Dan Wang, Yun Chen, Sulan Zhai, Zhiqin Zeng, Shusheng Wu, Mengting Lou, Junhong Chen, Jian Zou, Mingyue Zheng, Jun Qin, Xiaoming Wang
Targeting JMJD1C to selectively disrupt tumor T reg cell fitness enhances antitumor immunity. Nature immunology (2024)
Wenkai Xiang, Feisheng Zhong, Lin Ni, Mingyue Zheng, Xutong Li, Qian Shi, Dingyan Wang
Gram matrix: an efficient representation of molecular conformation and learning objective for molecular pretraining. Briefings in bioinformatics 25 (4) (2024)
Xiaochu Tong, Ning Qu, Xiangtai Kong, Shengkun Ni, Jingyi Zhou, Kun Wang, Lehan Zhang, Yiming Wen, Jiangshan Shi, Sulin Zhang, Xutong Li, Mingyue Zheng
Deep representation learning of chemical-induced transcriptional profile for phenotype-based drug discovery. Nature communications 15 (1) (2024)
Jinfeng Li, Bao Chen, Zunyun Fu, Jingjing Mao, Lijun Liu, Xiaochen Chen, Mingyue Zheng, Chang-Yun Wang, Chengyuan Wang, Yue-Wei Guo, Baofu Xu
Discovery of a terpene synthase synthesizing a nearly non-flexible eunicellane reveals the basis of flexibility. Nature communications 15 (1) (2024)
Hui Wang, Yanyang Zhang, Yu Tian, Wanlin Yang, Yan Wang, Hui Hou, Hanbo Pan, Siyu Pei, Hongda Zhu, Zenan Gu, Yanyun Zhang, Dongfang Dai, Wei Chen, Mingyue Zheng, Qingquan Luo, Yi-Chuan Xiao, Jia Huang
DNA-PK-Mediated Cytoplasmic DNA Sensing Stimulates Glycolysis to Promote Lung Squamous Cell Carcinoma Malignancy and Chemoresistance. Cancer research (2024)
Xin-Heng He, Lifen Zhao, Yinping Tian, Rui Li, Qinyu Chu, Zhiyong Gu, Mingyue Zheng, Yusong Wang, Shaoning Li, Hualiang Jiang, Yi Jiang, Liuqing Wen, Dingyan Wang, Xi Cheng
Highly accurate carbohydrate-binding site prediction with DeepGlycanSite. Nature communications 15 (1) (2024)
Zichao Xu, Xia Peng, Renjie Zhang, Yinchun Ji, Mengke You, Danyi Wang, Yanyan Shen, Mingyue Zheng, Chunpu Li, Jing Ai, Hong Liu
Discovery, Optimization, and Evaluation of Novel Pyridin-2(1 H )-one Analogues as Potent TRK Inhibitors for Cancer Treatment. Journal of medicinal chemistry (2024)
Mingan Chen, Xinyu Jiang, Lehan Zhang, Xiaoxu Chen, Yiming Wen, Zhiyong Gu, Xutong Li, Mingyue Zheng
The emergence of machine learning force fields in drug design. Medicinal research reviews 44 (3) (2024)
Xiaochu Tong, Ning Qu, Xiangtai Kong, Shengkun Ni, Jingyi Zhou, Kun Wang, Lehan Zhang, Yiming Wen, Jiangshan Shi, Sulin Zhang, Xutong Li, Mingyue Zheng
Deep representation learning of chemical-induced transcriptional profile for phenotype-based drug discovery. Nature communications 15 (1) (2024)
Xiong Xie, Qiaoshuai Lan, Jinyi Zhao, Sulin Zhang, Lu Liu, Yumin Zhang, Wei Xu, Maolin Shao, Jingjing Peng, Shuai Xia, Yan Zhu, Keke Zhang, Xianglei Zhang, Ruxue Zhang, Jian Li, Wenhao Dai, Zhen Ge, Shulei Hu, Changyue Yu, Jiang Wang, Dakota Ma, Mingyue Zheng, Haitao Yang, Geng-Fu Xiao, Zihe Rao, Lu Lu, Lei-Ke Zhang, Fang Bai, Yao Zhao, Shibo Jiang, Hong Liu
Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1. Signal transduction and targeted therapy 9 (1) (2024)
Zhaojun Li, Ning Qu, Jingyi Zhou, Jingjing Sun, Qun Ren, Jingyi Meng, Guangchao Wang, Rongyan Wang, Jin Liu, Yijie Chen, Sulin Zhang, Mingyue Zheng, Xutong Li
KinomeMETA: a web platform for kinome-wide polypharmacology profiling with meta-learning. Nucleic acids research 52 (W1) (2024)
Wei Zhang, Qinggong Wang, Xiangtai Kong, Jiacheng Xiong, Shengkun Ni, Duanhua Cao, Buying Niu, Mingan Chen, Yameng Li, Runze Zhang, Yitian Wang, Lehan Zhang, Xutong Li, Zhaoping Xiong, Qian Shi, Ziming Huang, Zunyun Fu, Mingyue Zheng
Fine-tuning large language models for chemical text mining. Chemical science 15 (27) (2024)
Chuan Zhou, Zisheng Fan, Yuejiao Gu, Zhiming Ge, Zhaofan Tao, Rongrong Cui, Yupeng Li, Guizhen Zhou, Ruifeng Huo, Mingshan Gao, Dan Wang, Wei He, Mingyue Zheng, Sulin Zhang, Tianfeng Xu
Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC Degraders of Oncogenic KRAS G12D . Journal of medicinal chemistry 67 (2) (2024)
Chuan Zhou, Zisheng Fan, Yuejiao Gu, Zhiming Ge, Zhaofan Tao, Rongrong Cui, Yupeng Li, Guizhen Zhou, Ruifeng Huo, Mingshan Gao, Dan Wang, Wei He, Mingyue Zheng, Sulin Zhang, Tianfeng Xu
Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC Degraders of Oncogenic KRAS G12D . Journal of medicinal chemistry (2024)
Xiaochu Tong, Ning Qu, Xiangtai Kong, Shengkun Ni, Jingyi Zhou, Kun Wang, Lehan Zhang, Yiming Wen, Jiangshan Shi, Sulin Zhang, Xutong Li, Mingyue Zheng
Deep representation learning of chemical-induced transcriptional profile for phenotype-based drug discovery. Nature communications 15 (1) (2024)
Wenkai Xiang, Feisheng Zhong, Lin Ni, Mingyue Zheng, Xutong Li, Qian Shi, Dingyan Wang
Gram matrix: an efficient representation of molecular conformation and learning objective for molecular pretraining. Briefings in bioinformatics 25 (4) (2024)
Huajie Li, Zhiming Ge, Kexin Lin, Wei He, Qinyu Chu, Mingyue Zheng, Sulin Zhang, Tianfeng Xu
Design, Synthesis, and Bioevaluation of Transcriptional Enhanced Assocciated Domain (TEAD) PROTAC Degraders. ACS medicinal chemistry letters 15 (5) (2024)
Zichao Xu, Xia Peng, Renjie Zhang, Yinchun Ji, Mengke You, Danyi Wang, Yanyan Shen, Mingyue Zheng, Chunpu Li, Jing Ai, Hong Liu
Discovery, Optimization, and Evaluation of Novel Pyridin-2(1 H )-one Analogues as Potent TRK Inhibitors for Cancer Treatment. Journal of medicinal chemistry 67 (2) (2024)
Xiong Xie, Qiaoshuai Lan, Jinyi Zhao, Sulin Zhang, Lu Liu, Yumin Zhang, Wei Xu, Maolin Shao, Jingjing Peng, Shuai Xia, Yan Zhu, Keke Zhang, Xianglei Zhang, Ruxue Zhang, Jian Li, Wenhao Dai, Zhen Ge, Shulei Hu, Changyue Yu, Jiang Wang, Dakota Ma, Mingyue Zheng, Haitao Yang, Geng-Fu Xiao, Zihe Rao, Lu Lu, Lei-Ke Zhang, Fang Bai, Yao Zhao, Shibo Jiang, Hong Liu
Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1. Signal transduction and targeted therapy 9 (1) (2024)
Zichao Xu, Xia Peng, Renjie Zhang, Yinchun Ji, Mengke You, Danyi Wang, Yanyan Shen, Mingyue Zheng, Chunpu Li, Jing Ai, Hong Liu
Discovery, Optimization, and Evaluation of Novel Pyridin-2(1 H )-one Analogues as Potent TRK Inhibitors for Cancer Treatment. Journal of medicinal chemistry 67 (2) (2024)
Xuehui Long, Sulin Zhang, Yuliang Wang, Jingjing Chen, Yanlai Lu, Hui Hou, Bichun Lin, Xutong Li, Chang Shen, Ruirui Yang, Huamin Zhu, Rongrong Cui, Duanhua Cao, Geng Chen, Dan Wang, Yun Chen, Sulan Zhai, Zhiqin Zeng, Shusheng Wu, Mengting Lou, Junhong Chen, Jian Zou, Mingyue Zheng, Jun Qin, Xiaoming Wang
Targeting JMJD1C to selectively disrupt tumor T reg cell fitness enhances antitumor immunity. Nature immunology 25 (3) (2024)
Kun Wang, Jiangshan Shi, Xiaochu Tong, Ning Qu, Xiangtai Kong, Shengkun Ni, Jing Xing, Xutong Li, Mingyue Zheng
TG468: a text graph convolutional network for predicting clinical response to immune checkpoint inhibitor therapy. Briefings in bioinformatics 25 (2) (2024)
Xuehui Long, Sulin Zhang, Yuliang Wang, Jingjing Chen, Yanlai Lu, Hui Hou, Bichun Lin, Xutong Li, Chang Shen, Ruirui Yang, Huamin Zhu, Rongrong Cui, Duanhua Cao, Geng Chen, Dan Wang, Yun Chen, Sulan Zhai, Zhiqin Zeng, Shusheng Wu, Mengting Lou, Junhong Chen, Jian Zou, Mingyue Zheng, Jun Qin, Xiaoming Wang
Targeting JMJD1C to selectively disrupt tumor T reg cell fitness enhances antitumor immunity. Nature immunology 25 (3) (2024)
Zhaojun Li, Ning Qu, Jingyi Zhou, Jingjing Sun, Qun Ren, Jingyi Meng, Guangchao Wang, Rongyan Wang, Jin Liu, Yijie Chen, Sulin Zhang, Mingyue Zheng, Xutong Li
KinomeMETA: a web platform for kinome-wide polypharmacology profiling with meta-learning. Nucleic acids research 52 (W1) (2024)
Huajie Li, Zhiming Ge, Kexin Lin, Wei He, Qinyu Chu, Mingyue Zheng, Sulin Zhang, Tianfeng Xu
Design, Synthesis, and Bioevaluation of Transcriptional Enhanced Assocciated Domain (TEAD) PROTAC Degraders. ACS medicinal chemistry letters 15 (5) (2024)
Chuan Zhou, Zisheng Fan, Yuejiao Gu, Zhiming Ge, Zhaofan Tao, Rongrong Cui, Yupeng Li, Guizhen Zhou, Ruifeng Huo, Mingshan Gao, Dan Wang, Wei He, Mingyue Zheng, Sulin Zhang, Tianfeng Xu
Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC Degraders of Oncogenic KRAS G12D . Journal of medicinal chemistry 67 (2) (2024)
Xiong Xie, Qiaoshuai Lan, Jinyi Zhao, Sulin Zhang, Lu Liu, Yumin Zhang, Wei Xu, Maolin Shao, Jingjing Peng, Shuai Xia, Yan Zhu, Keke Zhang, Xianglei Zhang, Ruxue Zhang, Jian Li, Wenhao Dai, Zhen Ge, Shulei Hu, Changyue Yu, Jiang Wang, Dakota Ma, Mingyue Zheng, Haitao Yang, Geng-Fu Xiao, Zihe Rao, Lu Lu, Lei-Ke Zhang, Fang Bai, Yao Zhao, Shibo Jiang, Hong Liu
Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1. Signal transduction and targeted therapy 9 (1) (2024)
Hui Wang, Yanyang Zhang, Yu Tian, Wanlin Yang, Yan Wang, Hui Hou, Hanbo Pan, Siyu Pei, Hongda Zhu, Zenan Gu, Yanyun Zhang, Dongfang Dai, Wei Chen, Mingyue Zheng, Qingquan Luo, Yi-Chuan Xiao, Jia Huang
DNA-PK-Mediated Cytoplasmic DNA Sensing Stimulates Glycolysis to Promote Lung Squamous Cell Carcinoma Malignancy and Chemoresistance. Cancer research 84 (5) (2024)
Zichao Xu, Xia Peng, Renjie Zhang, Yinchun Ji, Mengke You, Danyi Wang, Yanyan Shen, Mingyue Zheng, Chunpu Li, Jing Ai, Hong Liu
Discovery, Optimization, and Evaluation of Novel Pyridin-2(1 H )-one Analogues as Potent TRK Inhibitors for Cancer Treatment. Journal of medicinal chemistry 67 (2) (2024)
Xuehui Long, Sulin Zhang, Yuliang Wang, Jingjing Chen, Yanlai Lu, Hui Hou, Bichun Lin, Xutong Li, Chang Shen, Ruirui Yang, Huamin Zhu, Rongrong Cui, Duanhua Cao, Geng Chen, Dan Wang, Yun Chen, Sulan Zhai, Zhiqin Zeng, Shusheng Wu, Mengting Lou, Junhong Chen, Jian Zou, Mingyue Zheng, Jun Qin, Xiaoming Wang
Targeting JMJD1C to selectively disrupt tumor T reg cell fitness enhances antitumor immunity. Nature immunology 25 (3) (2024)
Mingan Chen, Xinyu Jiang, Lehan Zhang, Xiaoxu Chen, Yiming Wen, Zhiyong Gu, Xutong Li, Mingyue Zheng
The emergence of machine learning force fields in drug design. Medicinal research reviews 44 (3) (2024)
Jinfeng Li, Bao Chen, Zunyun Fu, Jingjing Mao, Lijun Liu, Xiaochen Chen, Mingyue Zheng, Chang-Yun Wang, Chengyuan Wang, Yue-Wei Guo, Baofu Xu
Discovery of a terpene synthase synthesizing a nearly non-flexible eunicellane reveals the basis of flexibility. Nature communications 15 (1) (2024)
Xuehui Long, Sulin Zhang, Yuliang Wang, Jingjing Chen, Yanlai Lu, Hui Hou, Bichun Lin, Xutong Li, Chang Shen, Ruirui Yang, Huamin Zhu, Rongrong Cui, Duanhua Cao, Geng Chen, Dan Wang, Yun Chen, Sulan Zhai, Zhiqin Zeng, Shusheng Wu, Mengting Lou, Junhong Chen, Jian Zou, Mingyue Zheng, Jun Qin, Xiaoming Wang
Targeting JMJD1C to selectively disrupt tumor T reg cell fitness enhances antitumor immunity. Nature immunology 25 (3) (2024)
Chuan Zhou, Zisheng Fan, Yuejiao Gu, Zhiming Ge, Zhaofan Tao, Rongrong Cui, Yupeng Li, Guizhen Zhou, Ruifeng Huo, Mingshan Gao, Dan Wang, Wei He, Mingyue Zheng, Sulin Zhang, Tianfeng Xu
Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC Degraders of Oncogenic KRAS G12D . Journal of medicinal chemistry 67 (2) (2024)
Chenmao Zhou, Xinyue Hao, Zhengyang Chen, Runze Zhang, Qian Zhou, Zisheng Fan, Mingyue Zheng, Hui Hou, Sulin Zhang, Hao Guo
Synthesis and Biological Evaluation of β-Lactam Derivatives Targeting Speckle-Type POZ Protein (SPOP). ACS medicinal chemistry letters 15 (2) (2024)
Chenmao Zhou, Xinyue Hao, Zhengyang Chen, Runze Zhang, Qian Zhou, Zisheng Fan, Mingyue Zheng, Hui Hou, Sulin Zhang, Hao Guo
Synthesis and Biological Evaluation of β-Lactam Derivatives Targeting Speckle-Type POZ Protein (SPOP). ACS medicinal chemistry letters 15 (2) (2024)
Xuehui Long, Sulin Zhang, Yuliang Wang, Jingjing Chen, Yanlai Lu, Hui Hou, Bichun Lin, Xutong Li, Chang Shen, Ruirui Yang, Huamin Zhu, Rongrong Cui, Duanhua Cao, Geng Chen, Dan Wang, Yun Chen, Sulan Zhai, Zhiqin Zeng, Shusheng Wu, Mengting Lou, Junhong Chen, Jian Zou, Mingyue Zheng, Jun Qin, Xiaoming Wang
Targeting JMJD1C to selectively disrupt tumor T reg cell fitness enhances antitumor immunity. Nature immunology 25 (3) (2024)
Wei Zhang, Qinggong Wang, Xiangtai Kong, Jiacheng Xiong, Shengkun Ni, Duanhua Cao, Buying Niu, Mingan Chen, Yameng Li, Runze Zhang, Yitian Wang, Lehan Zhang, Xutong Li, Zhaoping Xiong, Qian Shi, Ziming Huang, Zunyun Fu, Mingyue Zheng
Fine-tuning large language models for chemical text mining. Chemical science 15 (27) (2024)
Xin-Heng He, Lifen Zhao, Yinping Tian, Rui Li, Qinyu Chu, Zhiyong Gu, Mingyue Zheng, Yusong Wang, Shaoning Li, Hualiang Jiang, Yi Jiang, Liuqing Wen, Dingyan Wang, Xi Cheng
Highly accurate carbohydrate-binding site prediction with DeepGlycanSite. Nature communications 15 (1) (2024)
Jinfeng Li, Bao Chen, Zunyun Fu, Jingjing Mao, Lijun Liu, Xiaochen Chen, Mingyue Zheng, Chang-Yun Wang, Chengyuan Wang, Yue-Wei Guo, Baofu Xu
Discovery of a terpene synthase synthesizing a nearly non-flexible eunicellane reveals the basis of flexibility. Nature communications 15 (1) (2024)
Mingan Chen, Xinyu Jiang, Lehan Zhang, Xiaoxu Chen, Yiming Wen, Zhiyong Gu, Xutong Li, Mingyue Zheng
The emergence of machine learning force fields in drug design. Medicinal research reviews 44 (3) (2024)
Xiong Xie, Qiaoshuai Lan, Jinyi Zhao, Sulin Zhang, Lu Liu, Yumin Zhang, Wei Xu, Maolin Shao, Jingjing Peng, Shuai Xia, Yan Zhu, Keke Zhang, Xianglei Zhang, Ruxue Zhang, Jian Li, Wenhao Dai, Zhen Ge, Shulei Hu, Changyue Yu, Jiang Wang, Dakota Ma, Mingyue Zheng, Haitao Yang, Geng-Fu Xiao, Zihe Rao, Lu Lu, Lei-Ke Zhang, Fang Bai, Yao Zhao, Shibo Jiang, Hong Liu
Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1. Signal transduction and targeted therapy 9 (1) (2024)
Hui Wang, Yanyang Zhang, Yu Tian, Wanlin Yang, Yan Wang, Hui Hou, Hanbo Pan, Siyu Pei, Hongda Zhu, Zenan Gu, Yanyun Zhang, Dongfang Dai, Wei Chen, Mingyue Zheng, Qingquan Luo, Yi-Chuan Xiao, Jia Huang
DNA-PK-Mediated Cytoplasmic DNA Sensing Stimulates Glycolysis to Promote Lung Squamous Cell Carcinoma Malignancy and Chemoresistance. Cancer research 84 (5) (2024)
Zhaojun Li, Ning Qu, Jingyi Zhou, Jingjing Sun, Qun Ren, Jingyi Meng, Guangchao Wang, Rongyan Wang, Jin Liu, Yijie Chen, Sulin Zhang, Mingyue Zheng, Xutong Li
KinomeMETA: a web platform for kinome-wide polypharmacology profiling with meta-learning. Nucleic acids research (2024)
Mingan Chen, Xinyu Jiang, Lehan Zhang, Xiaoxu Chen, Yiming Wen, Zhiyong Gu, Xutong Li, Mingyue Zheng
The emergence of machine learning force fields in drug design. Medicinal research reviews (2024)
Chang Shen, Peijia Xu, Changfa Zhang, Zhaoming Su, Bin Shan, Rui Li, Qibang Sui, Keke Zhang, Zhengyang Chen, Jingyi Zhou, Xiaojie Lu, Kaixian Chen, Mingyue Zheng, Sulin Zhang, Hui Hou
Structure-Activity Relationship Study of 1 H -Pyrrole-3-carbonitrile Derivatives as STING Receptor Agonists. ACS medicinal chemistry letters 14 (8) (2023)
Zehui Zhou, Guizhen Zhou, Chuan Zhou, Zisheng Fan, Rongrong Cui, Yupeng Li, Rui Li, Yuejiao Gu, Huajie Li, Zhiming Ge, Xiaojia Cai, Bing Jiang, Dan Wang, Mingyue Zheng, Tianfeng Xu, Sulin Zhang
Discovery of a Potent, Cooperative, and Selective SOS1 PROTAC ZZ151 with In Vivo Antitumor Efficacy in KRAS-Mutant Cancers. Journal of medicinal chemistry (2023)
Qun Ren, Ning Qu, Jingjing Sun, Jingyi Zhou, Jin Liu, Lin Ni, Xiaochu Tong, Zimei Zhang, Xiangtai Kong, Yiming Wen, Yitian Wang, Dingyan Wang, Xiaomin Luo, Sulin Zhang, Mingyue Zheng, Xutong Li
KinomeMETA: meta-learning enhanced kinome-wide polypharmacology profiling. Briefings in bioinformatics 25 (1) (2023)
Qun Ren, Ning Qu, Jingjing Sun, Jingyi Zhou, Jin Liu, Lin Ni, Xiaochu Tong, Zimei Zhang, Xiangtai Kong, Yiming Wen, Yitian Wang, Dingyan Wang, Xiaomin Luo, Sulin Zhang, Mingyue Zheng, Xutong Li
KinomeMETA: meta-learning enhanced kinome-wide polypharmacology profiling. Briefings in bioinformatics 25 (1) (2023)
Jie Yu, Zhaojun Li, Geng Chen, Xiangtai Kong, Jie Hu, Dingyan Wang, Duanhua Cao, Yanbei Li, Ruifeng Huo, Gang Wang, Xiaohong Liu, Hualiang Jiang, Xutong Li, Xiaomin Luo, Mingyue Zheng
Computing the relative binding affinity of ligands based on a pairwise binding comparison network. Nature computational science 3 (10) (2023)
Yangyang Cao, Xiaohui Liu, Jingjing Zhang, Zhongmin Liu, Yan Fu, Dong Zhang, Mingyue Zheng, Hai Yan Zhang, Ming-Hua Xu
Design of a Coumarin-Based Fluorescent Probe for Efficient In Vivo Imaging of Amyloid-β Plaques. ACS chemical neuroscience 14 (5) (2023)
Yangyang Cao, Xiaohui Liu, Jingjing Zhang, Zhongmin Liu, Yan Fu, Dong Zhang, Mingyue Zheng, Hai Yan Zhang, Ming-Hua Xu
Design of a Coumarin-Based Fluorescent Probe for Efficient In Vivo Imaging of Amyloid-β Plaques. ACS chemical neuroscience 14 (5) (2023)
Jie Yu, Zhaojun Li, Geng Chen, Xiangtai Kong, Jie Hu, Dingyan Wang, Duanhua Cao, Yanbei Li, Ruifeng Huo, Gang Wang, Xiaohong Liu, Hualiang Jiang, Xutong Li, Xiaomin Luo, Mingyue Zheng
Computing the relative binding affinity of ligands based on a pairwise binding comparison network. Nature computational science 3 (10) (2023)
Yangyang Cao, Xiaohui Liu, Jingjing Zhang, Zhongmin Liu, Yan Fu, Dong Zhang, Mingyue Zheng, Hai Yan Zhang, Ming-Hua Xu
Design of a Coumarin-Based Fluorescent Probe for Efficient In Vivo Imaging of Amyloid-β Plaques. ACS chemical neuroscience 14 (5) (2023)
Jie Yu, Zhaojun Li, Geng Chen, Xiangtai Kong, Jie Hu, Dingyan Wang, Duanhua Cao, Yanbei Li, Ruifeng Huo, Gang Wang, Xiaohong Liu, Hualiang Jiang, Xutong Li, Xiaomin Luo, Mingyue Zheng
Computing the relative binding affinity of ligands based on a pairwise binding comparison network. Nature computational science 3 (10) (2023)
Lifan Chen, Zisheng Fan, Jie Chang, Ruirui Yang, Hui Hou, Hao Guo, Yinghui Zhang, Tianbiao Yang, Chenmao Zhou, Qibang Sui, Zhengyang Chen, Chen Zheng, Xinyue Hao, Keke Zhang, Rongrong Cui, Zehong Zhang, Hudson Ma, Yiluan Ding, Naixia Zhang, Xiaojie Lu, Xiaomin Luo, Hualiang Jiang, Sulin Zhang, Mingyue Zheng
Sequence-based drug design as a concept in computational drug design. Nature communications 14 (1) (2023)
Bin Shan, Hui Hou, Keke Zhang, Rui Li, Chang Shen, Zhengyang Chen, Peijia Xu, Rongrong Cui, Zhaoming Su, Changfa Zhang, Ruirui Yang, Guizhen Zhou, Yadan Liu, Hao Guo, Kaixian Chen, Wei Fu, Hualiang Jiang, Sulin Zhang, Mingyue Zheng
Design, Synthesis, and Biological Evaluation of Bipyridazine Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists. Journal of medicinal chemistry 66 (5) (2023)
Meiying Liu, Guizhen Zhou, Wenhong Su, Yuejiao Gu, Mingshan Gao, Kun Wang, Ruifeng Huo, Yupeng Li, Zehui Zhou, Kaixian Chen, Mingyue Zheng, Sulin Zhang, Tianfeng Xu
Design, Synthesis, and Bioevaluation of Pyrido[2,3- d ]pyrimidin-7-ones as Potent SOS1 Inhibitors. ACS medicinal chemistry letters 14 (2) (2023)
Zehui Zhou, Guizhen Zhou, Chuan Zhou, Zisheng Fan, Rongrong Cui, Yupeng Li, Rui Li, Yuejiao Gu, Huajie Li, Zhiming Ge, Xiaojia Cai, Bing Jiang, Dan Wang, Mingyue Zheng, Tianfeng Xu, Sulin Zhang
Discovery of a Potent, Cooperative, and Selective SOS1 PROTAC ZZ151 with In Vivo Antitumor Efficacy in KRAS-Mutant Cancers. Journal of medicinal chemistry 66 (6) (2023)
Bin Shan, Hui Hou, Keke Zhang, Rui Li, Chang Shen, Zhengyang Chen, Peijia Xu, Rongrong Cui, Zhaoming Su, Changfa Zhang, Ruirui Yang, Guizhen Zhou, Yadan Liu, Hao Guo, Kaixian Chen, Wei Fu, Hualiang Jiang, Sulin Zhang, Mingyue Zheng
Design, Synthesis, and Biological Evaluation of Bipyridazine Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists. Journal of medicinal chemistry 66 (5) (2023)
Yangyang Cao, Xiaohui Liu, Jingjing Zhang, Zhongmin Liu, Yan Fu, Dong Zhang, Mingyue Zheng, Hai Yan Zhang, Ming-Hua Xu
Design of a Coumarin-Based Fluorescent Probe for Efficient In Vivo Imaging of Amyloid-β Plaques. ACS chemical neuroscience (2023)
Lei Zhou, Wenzhe Yi, Zehong Zhang, Xiaoting Shan, Zitong Zhao, Xiangshi Sun, Jue Wang, Hao Wang, Hualiang Jiang, Mingyue Zheng, Dangge Wang, Yaping Li
STING agonist-boosted mRNA immunization via intelligent design of nanovaccines for enhancing cancer immunotherapy. National science review 10 (10) (2023)
Chunpu Li, Yang Dai, Xiangtai Kong, Bao Wang, Xia Peng, Hengbo Wu, Yanyan Shen, Yanchen Yang, Yinchun Ji, Danyi Wang, Shuangjie Li, Xutong Li, Yuqiang Shi, Meiyu Geng, Mingyue Zheng, Jing Ai, Hong Liu
Structural Optimization of Fibroblast Growth Factor Receptor Inhibitors for Treating Solid Tumors. Journal of medicinal chemistry 66 (5) (2023)
Bin Shan, Hui Hou, Keke Zhang, Rui Li, Chang Shen, Zhengyang Chen, Peijia Xu, Rongrong Cui, Zhaoming Su, Changfa Zhang, Ruirui Yang, Guizhen Zhou, Yadan Liu, Hao Guo, Kaixian Chen, Wei Fu, Hualiang Jiang, Sulin Zhang, Mingyue Zheng
Design, Synthesis, and Biological Evaluation of Bipyridazine Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists. Journal of medicinal chemistry (2023)
Chunpu Li, Yang Dai, Xiangtai Kong, Bao Wang, Xia Peng, Hengbo Wu, Yanyan Shen, Yanchen Yang, Yinchun Ji, Danyi Wang, Shuangjie Li, Xutong Li, Yuqiang Shi, Meiyu Geng, Mingyue Zheng, Jing Ai, Hong Liu
Structural Optimization of Fibroblast Growth Factor Receptor Inhibitors for Treating Solid Tumors. Journal of medicinal chemistry (2023)
Bin Shan, Hui Hou, Keke Zhang, Rui Li, Chang Shen, Zhengyang Chen, Peijia Xu, Rongrong Cui, Zhaoming Su, Changfa Zhang, Ruirui Yang, Guizhen Zhou, Yadan Liu, Hao Guo, Kaixian Chen, Wei Fu, Hualiang Jiang, Sulin Zhang, Mingyue Zheng
Design, Synthesis, and Biological Evaluation of Bipyridazine Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists. Journal of medicinal chemistry 66 (5) (2023)
Chunpu Li, Yang Dai, Xiangtai Kong, Bao Wang, Xia Peng, Hengbo Wu, Yanyan Shen, Yanchen Yang, Yinchun Ji, Danyi Wang, Shuangjie Li, Xutong Li, Yuqiang Shi, Meiyu Geng, Mingyue Zheng, Jing Ai, Hong Liu
Structural Optimization of Fibroblast Growth Factor Receptor Inhibitors for Treating Solid Tumors. Journal of medicinal chemistry 66 (5) (2023)
Chunpu Li, Yang Dai, Xiangtai Kong, Bao Wang, Xia Peng, Hengbo Wu, Yanyan Shen, Yanchen Yang, Yinchun Ji, Danyi Wang, Shuangjie Li, Xutong Li, Yuqiang Shi, Meiyu Geng, Mingyue Zheng, Jing Ai, Hong Liu
Structural Optimization of Fibroblast Growth Factor Receptor Inhibitors for Treating Solid Tumors. Journal of medicinal chemistry 66 (5) (2023)
Jie Yu, Zhaojun Li, Geng Chen, Xiangtai Kong, Jie Hu, Dingyan Wang, Duanhua Cao, Yanbei Li, Ruifeng Huo, Gang Wang, Xiaohong Liu, Hualiang Jiang, Xutong Li, Xiaomin Luo, Mingyue Zheng
Computing the relative binding affinity of ligands based on a pairwise binding comparison network. Nature computational science 3 (10) (2023)
Zehui Zhou, Guizhen Zhou, Chuan Zhou, Zisheng Fan, Rongrong Cui, Yupeng Li, Rui Li, Yuejiao Gu, Huajie Li, Zhiming Ge, Xiaojia Cai, Bing Jiang, Dan Wang, Mingyue Zheng, Tianfeng Xu, Sulin Zhang
Discovery of a Potent, Cooperative, and Selective SOS1 PROTAC ZZ151 with In Vivo Antitumor Efficacy in KRAS-Mutant Cancers. Journal of medicinal chemistry 66 (6) (2023)
Meiying Liu, Guizhen Zhou, Wenhong Su, Yuejiao Gu, Mingshan Gao, Kun Wang, Ruifeng Huo, Yupeng Li, Zehui Zhou, Kaixian Chen, Mingyue Zheng, Sulin Zhang, Tianfeng Xu
Design, Synthesis, and Bioevaluation of Pyrido[2,3- d ]pyrimidin-7-ones as Potent SOS1 Inhibitors. ACS medicinal chemistry letters 14 (2) (2023)
Yi Zang, Mingbo Su, Qingxing Wang, Xi Cheng, Wenru Zhang, Yao Zhao, Tong Chen, Yingyan Jiang, Qiang Shen, Juan Du, Qiuxiang Tan, Peipei Wang, Lixin Gao, Zhenming Jin, Mengmeng Zhang, Cong Li, Ya Zhu, Bo Feng, Bixi Tang, Han Xie, Ming-Wei Wang, Mingyue Zheng, Xiaoyan Pan, Haitao Yang, Yechun Xu, Beili Wu, Leike Zhang, Zihe Rao, Xiuna Yang, Hualiang Jiang, Gengfu Xiao, Qiang Zhao, Jia Li
High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors. Protein & cell 14 (1) (2022)
Yi Zang, Mingbo Su, Qingxing Wang, Xi Cheng, Wenru Zhang, Yao Zhao, Tong Chen, Yingyan Jiang, Qiang Shen, Juan Du, Qiuxiang Tan, Peipei Wang, Lixin Gao, Zhenming Jin, Mengmeng Zhang, Cong Li, Ya Zhu, Bo Feng, Bixi Tang, Han Xie, Ming-Wei Wang, Mingyue Zheng, Xiaoyan Pan, Haitao Yang, Yechun Xu, Beili Wu, Leike Zhang, Zihe Rao, Xiuna Yang, Hualiang Jiang, Gengfu Xiao, Qiang Zhao, Jia Li
High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors. Protein & cell 14 (1) (2022)
Yi Zang, Mingbo Su, Qingxing Wang, Xi Cheng, Wenru Zhang, Yao Zhao, Tong Chen, Yingyan Jiang, Qiang Shen, Juan Du, Qiuxiang Tan, Peipei Wang, Lixin Gao, Zhenming Jin, Mengmeng Zhang, Cong Li, Ya Zhu, Bo Feng, Bixi Tang, Han Xie, Ming-Wei Wang, Mingyue Zheng, Xiaoyan Pan, Haitao Yang, Yechun Xu, Beili Wu, Leike Zhang, Zihe Rao, Xiuna Yang, Hualiang Jiang, Gengfu Xiao, Qiang Zhao, Jia Li
High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors. Protein & cell 14 (1) (2022)
Cheng-Long Hu, Bing-Yi Chen, Zijuan Li, Tianbiao Yang, Chun-Hui Xu, Ruirui Yang, Peng-Cheng Yu, Jingyao Zhao, Ting Liu, Na Liu, Bin Shan, Qunling Zhang, Junhong Song, Ming-Yue Fei, Li-Juan Zong, Jia-Ying Zhang, Ji-Chuan Wu, Shu-Bei Chen, Yong Wang, Binhe Chang, Dan Hou, Ping Liu, Yilun Jiang, Xiya Li, Xinchi Chen, Chu-Han Deng, Yi-Yi Ren, Roujia Wang, Jiacheng Jin, Kai Xue, Ying Zhang, Meirong Du, Jun Shi, Ling-Yun Wu, Chun-Kang Chang, Shuhong Shen, Zhu Chen, Sai-Juan Chen, Xiaolong Liu, Xiao-Jian Sun, Mingyue Zheng, Lan Wang
Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia. Cell research 32 (12) (2022)
Jing Gao, Bo Hou, Qiwen Zhu, Lei Yang, Xingyu Jiang, Zhifeng Zou, Xutong Li, Tianfeng Xu, Mingyue Zheng, Yi-Hung Chen, Zhiai Xu, Hui-Xiong Xu, Haijun Yu
Author Correction: Engineered bioorthogonal POLY-PROTAC nanoparticles for tumour-specific protein degradation and precise cancer therapy. Nature communications 13 (1) (2022)
Jing Gao, Bo Hou, Qiwen Zhu, Lei Yang, Xingyu Jiang, Zhifeng Zou, Xutong Li, Tianfeng Xu, Mingyue Zheng, Yi-Hung Chen, Zhiai Xu, Hui-Xiong Xu, Haijun Yu
Engineered bioorthogonal POLY-PROTAC nanoparticles for tumour-specific protein degradation and precise cancer therapy. Nature communications 13 (1) (2022)
Chuan Zhou, Zisheng Fan, Zehui Zhou, Yupeng Li, Rongrong Cui, Chaoyi Liu, Guizhen Zhou, Xingxing Diao, Hualiang Jiang, Mingyue Zheng, Sulin Zhang, Tianfeng Xu
Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations. Journal of medicinal chemistry 65 (5) (2022)
Yi Zang, Mingbo Su, Qingxing Wang, Xi Cheng, Wenru Zhang, Yao Zhao, Tong Chen, Yingyan Jiang, Qiang Shen, Juan Du, Qiuxiang Tan, Peipei Wang, Lixin Gao, Zhenming Jin, Mengmeng Zhang, Cong Li, Ya Zhu, Bo Feng, Bixi Tang, Han Xie, Ming-Wei Wang, Mingyue Zheng, Xiaoyan Pan, Haitao Yang, Yechun Xu, Beili Wu, Leike Zhang, Zihe Rao, Xiuna Yang, Hualiang Jiang, Gengfu Xiao, Qiang Zhao, Jia Li
High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors. Protein & cell 14 (1) (2022)
Feisheng Zhong, Xiaolong Wu, Ruirui Yang, Xutong Li, Dingyan Wang, Zunyun Fu, Xiaohong Liu, XiaoZhe Wan, Tianbiao Yang, Zisheng Fan, Yinghui Zhang, Xiaomin Luo, Kaixian Chen, Sulin Zhang, Hualiang Jiang, Mingyue Zheng
Drug target inference by mining transcriptional data using a novel graph convolutional network framework. Protein & cell (2021)
Xiaoyu Ding, Rongrong Cui, Jie Yu, Tiantian Liu, Tingfei Zhu, Dingyan Wang, Jie Chang, Zisheng Fan, Xiaomeng Liu, Kaixian Chen, Hualiang Jiang, Xutong Li, Xiaomin Luo, Mingyue Zheng
Active Learning for Drug Design: A Case Study on the Plasma Exposure of Orally Administered Drugs. Journal of medicinal chemistry 64 (22) (2021)
Xiaochu Tong, Xiaohong Liu, Xiaoqin Tan, Xutong Li, Jiaxin Jiang, Zhaoping Xiong, Tingyang Xu, Hualiang Jiang, Nan Qiao, Mingyue Zheng
Generative Models for De Novo Drug Design. Journal of medicinal chemistry 64 (19) (2021)
Xiaoqin Tan, Chunpu Li, Ruirui Yang, Sen Zhao, Fei Li, Xutong Li, Lifan Chen, Xiaozhe Wan, Xiaohong Liu, Tianbiao Yang, Xiaochu Tong, Tingyang Xu, Rongrong Cui, Hualiang Jiang, Sulin Zhang, Hong Liu, Mingyue Zheng
Discovery of Pyrazolo[3,4-d]pyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation. Journal of medicinal chemistry (2021)
Yaxi Yang, Rukang Zhang, Zhaojun Li, Lianghe Mei, Shili Wan, Hong Ding, Zhifeng Chen, Jing Xing, Huijin Feng, Jie Han, Hualiang Jiang, Mingyue Zheng, Cheng Luo, Bing Zhou
Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors. Journal of medicinal chemistry 63 (3) (2020)
Jihui Zhao, Rongrong Cui, Lihao Wang, Yingjia Chen, Zunyun Fu, Xiaoyu Ding, Chen Cui, Tianbiao Yang, Xutong Li, Yuan Xu, Kaixian Chen, Xiaomin Luo, Hualiang Jiang, Mingyue Zheng
Revisiting Aldehyde Oxidase Mediated Metabolism in Drug-like Molecules: An Improved Computational Model. Journal of medicinal chemistry 63 (12) (2020)
Xutong Li, Zhaojun Li, Xiaolong Wu, Zhaoping Xiong, Tianbiao Yang, Zunyun Fu, Xiaohong Liu, Xiaoqin Tan, Feisheng Zhong, Xiaozhe Wan, Dingyan Wang, Xiaoyu Ding, Ruirui Yang, Hui Hou, Chunpu Li, Hong Liu, Kaixian Chen, Hualiang Jiang, Mingyue Zheng
Deep Learning Enhancing Kinome-Wide Polypharmacology Profiling: Model Construction and Experiment Validation. Journal of medicinal chemistry 63 (16) (2019)
Yulan Wang, Yang Dai, Xiaowei Wu, Fei Li, Bo Liu, Chunpu Li, Qiufeng Liu, Yuanyang Zhou, Bao Wang, Mingrui Zhu, Rongrong Cui, Xiaoqin Tan, Zhaoping Xiong, Jia Liu, Min-Jia Tan, Yechun Xu, Meiyu Geng, Hualiang Jiang, Hong Liu, Jing Ai, Mingyue Zheng
Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design. Journal of medicinal chemistry 62 (16) (2019)
Zhaoping Xiong, Dingyan Wang, Xiaohong Liu, Feisheng Zhong, Xiaozhe Wan, Xutong Li, Zhaojun Li, Xiaomin Luo, Kaixian Chen, Hualiang Jiang, Mingyue Zheng
Pushing the Boundaries of Molecular Representation for Drug Discovery with the Graph Attention Mechanism. Journal of medicinal chemistry 63 (16) (2019)
Mingyue Zheng, Jihui Zhao, Chen Cui, Zunyun Fu, Xutong Li, Xiaohong Liu, Xiaoyu Ding, Xiaoqin Tan, Fei Li, Xiaomin Luo, Kaixian Chen, Hualiang Jiang
Computational chemical biology and drug design: Facilitating protein structure, function, and modulation studies. Medicinal research reviews 38 (3) (2018)
Yuan Xu, Liang Li, Yulan Wang, Jing Xing, Lei Zhou, Dafang Zhong, Xiaomin Luo, Hualiang Jiang, Kaixian Chen, Mingyue Zheng, Pan Deng, Xiaoyan Chen
Aldehyde Oxidase Mediated Metabolism in Drug-like Molecules: A Combined Computational and Experimental Study. Journal of medicinal chemistry 60 (7) (2017)
Jing Xing, Wenchao Lu, Rongfeng Liu, Yulan Wang, Yiqian Xie, Hao Zhang, Zhe Shi, Hao Jiang, Yu-Chih Liu, Kaixian Chen, Hualiang Jiang, Cheng Luo, Mingyue Zheng
Machine-Learning-Assisted Approach for Discovering Novel Inhibitors Targeting Bromodomain-Containing Protein 4. Journal of chemical information and modeling 57 (7) (2017)
Yulan Wang, Linjuan Li, Bidong Zhang, Jing Xing, Shijie Chen, Wei Wan, Yakai Song, Hao Jiang, Hualiang Jiang, Cheng Luo, Mingyue Zheng
Discovery of Novel Disruptor of Silencing Telomeric 1-Like (DOT1L) Inhibitors using a Target-Specific Scoring Function for the (S)-Adenosyl-l-methionine (SAM)-Dependent Methyltransferase Family. Journal of medicinal chemistry 60 (5) (2017)
Zhifeng Chen, Hao Zhang, Shien Liu, Yiqian Xie, Hao Jiang, Wenchao Lu, Heng Xu, Liyan Yue, Yuanyuan Zhang, Hong Ding, Mingyue Zheng, Kunqian Yu, Kaixian Chen, Hualiang Jiang, Cheng Luo
Discovery of novel trimethoxy-ring BRD4 bromodomain inhibitors: AlphaScreen assay, crystallography and cell-based assay. MedChemComm 8 (6) (2017)
Wei Zhu, Hui Chen, Yulan Wang, Jiang Wang, Xia Peng, Xianjie Chen, Yinglei Gao, Chunpu Li, Yulong He, Jing Ai, Meiyu Geng, Mingyue Zheng, Hong Liu
Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer. Journal of medicinal chemistry 60 (14) (2017)
Tao Huang, Lei Chen, Jiangning Song, Mingyue Zheng, Jialiang Yang, Zhenguo Zhang
Integrated Analysis of Multiscale Large-Scale Biological Data for Investigating Human Disease 2016. BioMed research international 2016 (2016)
Guohua Huang, Yin Lu, Changhong Lu, Mingyue Zheng, Yu-Dong Cai
Prediction of drug indications based on chemical interactions and chemical similarities. BioMed research international 2015 (2015)
Tao Huang, Lei Chen, Mingyue Zheng, Jiangning Song
Integrated analysis of multiscale large-scale biological data for investigating human disease. BioMed research international 2015 (2015)
Lu Jin, Fei Ye, Dan Zhao, Shijie Chen, Kongkai Zhu, Mingyue Zheng, Ren-Wang Jiang, Hualiang Jiang, Cheng Luo
Metadynamics simulation study on the conformational transformation of HhaI methyltransferase: an induced-fit base-flipping hypothesis. BioMed research international 2014 (2014)

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