Identification of a Metabolic, Transcriptomic, and Molecular Signature of Patatin-Like Phospholipase Domain Containing 3-Mediated Acceleration of Steatohepatitis.
Bubu A BaniniDivya P KumarSophie CazanaveMulugeta SeneshawFaridoddin MirshahiPrasanna K SanthekadurLiangsu WangHong Ping GuanAbdul M OseiniCristina AlonsoPierre BedossaSrinivas V KoduruHae-Ki MinArun J SanyalPublished in: Hepatology (Baltimore, Md.) (2021)
Under WDSW, PNPLA3I148M overexpression promotes steatosis and NASH by metabolic reprogramming characterized by increased triglycerides and diglycerides, n3 polyunsaturated fatty acid depletion, and increased ceramides with resultant STAT3 phosphorylation and downstream inflammatory pathway activation driving increased stellate cell fibrogenic activity.