Comparative effectiveness of second line glucose lowering drug treatments using real world data: emulation of a target trial.

Yihong DengEric C PolleyJoshua D WallachJeph HerrinJoseph R Ross Rozalina Grubina McCoy

Published in: BMJ medicine (2023)

In this target trial emulation of an expanded GRADE study framework, liraglutide was more effective in achieving and maintaining glycaemic control as a second line glucose lowering drug than canagliflozin, sitagliptin, or glimepiride.

Keyphrases

phase iii
study protocol
clinical trial
phase ii
blood glucose
type diabetes
electronic health record
randomized controlled trial
big data
blood pressure
open label
drug induced
machine learning
insulin resistance
artificial intelligence