Concordance between gene expression in peripheral whole blood and colonic tissue in children with inflammatory bowel disease.

Nathan P PalmerJocelyn Anne SilvesterJessica J LeeAndrew L BeamInbar FriedVladimir I ValtchinovFedik RahimovSek Won KongSaum GhodoussipourHelen C HoodAthos BousvarosRichard J GrandLouis M KunkelIsaac S Kohane

Published in: PloS one (2019)

Blood and colon tissue from patients with IBD share a common transcriptional profile dominated by immune and metabolic pathways. Our results suggest that peripheral blood expression levels of as few as 6 genes (IL7R, UBB, TXNIP, S100A8, ALAS2, and SLC2A3) may distinguish patients with IBD from non-IBD.

Keyphrases

gene expression
ulcerative colitis
peripheral blood
poor prognosis
young adults
transcription factor
genome wide
nlrp inflammasome