Influence of equipment changes on MRI measures of brain atrophy and brain microstructure in a placebo-controlled trial of ibudilast in progressive multiple sclerosis.

Ken E SakaieJanel K FedlerJon W YankeyKunio NakamuraJosef DebbinsMark J LowePaola RaskaRobert J Fox

Published in: Multiple sclerosis journal - experimental, translational and clinical (2021)

The results suggest that differences among hardware types should be considered when planning and analyzing brain atrophy and diffusivity in a longitudinal clinical trial.

Keyphrases

white matter
multiple sclerosis
resting state
clinical trial
functional connectivity
magnetic resonance imaging
cerebral ischemia
double blind
study protocol
computed tomography
randomized controlled trial
diffusion weighted imaging