Significantly altered peripheral blood cell DNA methylation profile as a result of immediate effect of metformin use in healthy individuals.

Ilze ElbereIvars SilamikelisMonta UstinovaIneta KalninaLinda ZaharenkoRaitis PeculisIlze KonradeDiana Maria CiuculeteChristina ZhukovskyDita GudraIlze Radovica-SpalvinaDavids FridmanisValdis PiragsHelgi B SchiöthJanis Klovins

Published in: Clinical epigenetics (2018)

EU Clinical Trials Register, 2016-001092-74. Registered 23 March 2017, https://www.clinicaltrialsregister.eu/ctr-search/trial/2016-001092-74/LV .

Keyphrases

peripheral blood
clinical trial
dna methylation
phase ii
phase iii
single cell
study protocol
gene expression
genome wide
cell therapy
open label
stem cells
double blind
copy number
randomized controlled trial