Hydrated Rubrolides from the New Zealand Tunicate Synoicum kuranui.
Joe BracegirdleLuke J StevensonAbigail V SharrockMichael J PageJan A VorsterJeremy G OwenDavid F AckerleyJoanne E HarveyPublished in: Journal of natural products (2021)
LCMS analysis of an extract of the New Zealand tunicate Synoicum kuranui showed evidence for numerous new rubrolides. Following a mass spectrometry-guided isolation procedure, new hydrated rubrolides V and W (5 and 6), along with previously reported rubrolide G (3), were isolated and characterized using MS and NMR. The anti-bacterial and cell cytotoxic activity of the compounds were compared to the potent anti-MRSA compound rubrolide A; hydration across the C-5/C-6 bond was shown to abrogate antibacterial activity.
Keyphrases
- mass spectrometry
- high resolution
- liquid chromatography
- magnetic resonance
- staphylococcus aureus
- single cell
- anti inflammatory
- methicillin resistant staphylococcus aureus
- multiple sclerosis
- oxidative stress
- cell therapy
- gas chromatography
- minimally invasive
- ms ms
- capillary electrophoresis
- solid state
- stem cells
- tandem mass spectrometry