David F Ackerley

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2014-2024
Publications (10 Years): 34

Top Topics

Escherichia Coli

Crystal Structure

Top Venues

International journal of molecular sciences

Journal of natural products

Biotechnology letters

This page only lists publications with an associated author ORCID identifier.

Publications

Abigail V Sharrock, Jeff S Mumm, Elsie M Williams, Narimantas Čėnas, Jeff B Smaill, Adam V Patterson, David F Ackerley, Gintautas Bagdžiūnas, Vickery L Arcus
Structural Evaluation of a Nitroreductase Engineered for Improved Activation of the 5-Nitroimidazole PET Probe SN33623. International journal of molecular sciences 25 (12) (2024)
Benjaminas Valiauga, Gintautas Bagdžiūnas, Abigail V Sharrock, David F Ackerley, Narimantas Čėnas
The Catalysis Mechanism of E. coli Nitroreductase A, a Candidate for Gene-Directed Prodrug Therapy: Potentiometric and Substrate Specificity Studies. International journal of molecular sciences 25 (8) (2024)
Abigail V Sharrock, Jeff S Mumm, Elsie M Williams, Narimantas Čėnas, Jeff B Smaill, Adam V Patterson, David F Ackerley, Gintautas Bagdžiūnas, Vickery L Arcus
Structural Evaluation of a Nitroreductase Engineered for Improved Activation of the 5-Nitroimidazole PET Probe SN33623. International journal of molecular sciences 25 (12) (2024)
Abigail V Sharrock, Jeff S Mumm, Elsie M Williams, Narimantas Čėnas, Jeff B Smaill, Adam V Patterson, David F Ackerley, Gintautas Bagdžiūnas, Vickery L Arcus
Structural Evaluation of a Nitroreductase Engineered for Improved Activation of the 5-Nitroimidazole PET Probe SN33623. International journal of molecular sciences 25 (12) (2024)
Benjaminas Valiauga, Gintautas Bagdžiūnas, Abigail V Sharrock, David F Ackerley, Narimantas Čėnas
The Catalysis Mechanism of E. coli Nitroreductase A, a Candidate for Gene-Directed Prodrug Therapy: Potentiometric and Substrate Specificity Studies. International journal of molecular sciences 25 (8) (2024)
Sarah R Messenger, David F Ackerley, Mark J Calcott
Heterologous Expression of Epoxomicin in Escherichia coli . ACS synthetic biology (2024)
Abigail V Sharrock, Jeff S Mumm, Gintautas Bagdžiūnas, Narimantas Čėnas, Vickery L Arcus, David F Ackerley
The Crystal Structure of Engineered Nitroreductase NTR 2.0 and Impact of F70A and F108Y Substitutions on Substrate Specificity. International journal of molecular sciences 24 (7) (2023)
Mitch Ganley, Lauren E Holz, Jordan J Minnell, Maria N de Menezes, Olivia K Burn, Kean Chan Yew Poa, Sarah L Draper, Kieran English, Susanna T S Chan, Regan J Anderson, Benjamin J Compton, Andrew J Marshall, Anton Cozijnsen, Yu Cheng Chua, Zhengyu Ge, Kathryn J Farrand, John C Mamum, Calvin Xu, Ian A Cockburn, Katsuyuki Yui, Patrick Bertolino, Stephanie Gras, Jérôme Le Nours, Jamie Rossjohn, Daniel Fernandez-Ruiz, Geoffrey I McFadden, David F Ackerley, Gavin A Painter, Ian F Hermans, William R Heath
mRNA vaccine against malaria tailored for liver-resident memory T cells. Nature immunology (2023)
Sarah R Messenger, Edward M R McGuinniety, Luke J Stevenson, Jeremy G Owen, Gregory L Challis, David F Ackerley, Mark J Calcott
Metagenomic domain substitution for the high-throughput modification of nonribosomal peptides. Nature chemical biology (2023)
Michelle H Rich, Abigail V Sharrock, Timothy S Mulligan, Frazer Matthews, Alistair S Brown, Hannah R Lee-Harwood, Elsie M Williams, Janine N Copp, Rory F Little, Jenni Jb Francis, Claire N Horvat, Luke J Stevenson, Jeremy G Owen, Meera T Saxena, Jeff S Mumm, David F Ackerley
A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening. bioRxiv : the preprint server for biology (2023)
Abigail V Sharrock, Timothy S Mulligan, Kelsi R Hall, Elsie M Williams, David T White, Liyun Zhang, Kevin Emmerich, Frazer Matthews, Saumya Nimmagadda, Selena Washington, Katherine D Le, Danielle Meir-Levi, Olivia L Cox, Meera T Saxena, Anne L Calof, Martha E Lopez-Burks, Arthur D Lander, Ding Ding, Hongkai Ji, David F Ackerley, Jeff S Mumm
NTR 2.0: a rationally engineered prodrug-converting enzyme with substantially enhanced efficacy for targeted cell ablation. Nature methods 19 (2) (2022)
Amir Ashoorzadeh, Alexandra M Mowday, Christopher P Guise, Shevan Silva, Matthew R Bull, Maria R Abbattista, Janine N Copp, Elsie M Williams, David F Ackerley, Adam V Patterson, Jeff B Smaill
Interrogation of the Structure-Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications. Pharmaceuticals (Basel, Switzerland) 15 (2) (2022)
Alexandra M Mowday, Ludwig J Dubois, Aleksandra M Kubiak, Jasmine V E Chan-Hyams, Christopher P Guise, Amir Ashoorzadeh, Philippe Lambin, David F Ackerley, Jeff B Smaill, Nigel Peter Minton, Jan Theys, Adam V Patterson
Use of an optimised enzyme/prodrug combination for Clostridia directed enzyme prodrug therapy induces a significant growth delay in necrotic tumours. Cancer gene therapy (2021)
Maria R Abbattista, Amir Ashoorzadeh, Christopher P Guise, Alexandra M Mowday, Rituparna Mittra, Shevan Silva, Kevin O Hicks, Matthew R Bull, Victoria Jackson-Patel, Xiaojing Lin, Gareth A Prosser, Neil K Lambie, Gabi U Dachs, David F Ackerley, Jeff B Smaill, Adam V Patterson
Restoring Tumour Selectivity of the Bioreductive Prodrug PR-104 by Developing an Analogue Resistant to Aerobic Metabolism by Human Aldo-Keto Reductase 1C3. Pharmaceuticals (Basel, Switzerland) 14 (12) (2021)
Joe Bracegirdle, Peng Hou, Vincent V Nowak, David F Ackerley, Joanne E Harvey, Jeremy G Owen
Skyllamycins D and E, Non-Ribosomal Cyclic Depsipeptides from Lichen-Sourced Streptomyces anulatus. Journal of natural products 84 (9) (2021)
Luke J Stevenson, Joe Bracegirdle, Liwei Liu, Abigail V Sharrock, David F Ackerley, Joanne E Harvey, Jeremy G Owen
Metathramycin, a new bioactive aureolic acid discovered by heterologous expression of a metagenome derived biosynthetic pathway. RSC chemical biology 2 (2) (2021)
Alistair S Brown, Jeremy G Owen, James Jung, Edward N Baker, David F Ackerley
Inhibition of Indigoidine Synthesis as a High-Throughput Colourimetric Screen for Antibiotics Targeting the Essential Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT. Pharmaceutics 13 (7) (2021)
Liyun Zhang, Conan Chen, Jie Fu, Brendan Lilley, Cynthia Berlinicke, Baranda Hansen, Ding Ding, Guohua Wang, Tao Wang, Daniel Shou, Ying Ye, Timothy Mulligan, Kevin Emmerich, Meera T Saxena, Kelsi R Hall, Abigail V Sharrock, Carlene Brandon, Hyejin Park, Tae-In Kam, Valina L Dawson, Ted M Dawson, Joong Sup Shim, Justin Hanes, Hongkai Ji, Jun O Liu, Jiang Qian, David F Ackerley, Baerbel Rohrer, Donald J Zack, Jeff S Mumm
Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa. eLife 10 (2021)
Joe Bracegirdle, Luke J Stevenson, Abigail V Sharrock, Michael J Page, Jan A Vorster, Jeremy G Owen, David F Ackerley, Joanne E Harvey
Hydrated Rubrolides from the New Zealand Tunicate Synoicum kuranui. Journal of natural products 84 (2) (2021)
Mark J Calcott, Jeremy G Owen, David F Ackerley
Efficient rational modification of non-ribosomal peptides by adenylation domain substitution. Nature communications 11 (1) (2020)
Janine N Copp, Daniel Pletzer, Alistair S Brown, Joris Van der Heijden, Charlotte M Miton, Rebecca J Edgar, Michelle H Rich, Rory F Little, Elsie M Williams, Robert E W Hancock, Nobuhiko Tokuriki, David F Ackerley
Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections. mBio 11 (5) (2020)
Alistair S Brown, Jack A Sissons, Jeremy G Owen, David F Ackerley
Directed Evolution of the Nonribosomal Peptide Synthetase BpsA to Enable Recognition by the Human Phosphopantetheinyl Transferase for Counter-Screening Antibiotic Candidates. ACS infectious diseases 6 (11) (2020)
Alistair S Brown, Mark J Calcott, Vincent M Collins, Jeremy G Owen, David F Ackerley
The indigoidine synthetase BpsA provides a colorimetric ATP assay that can be adapted to quantify the substrate preferences of other NRPS enzymes. Biotechnology letters 42 (12) (2020)
Mathew A Storey, Sarah K Andreassend, Joe Bracegirdle, Alistair Brown, Robert A Keyzers, David F Ackerley, Peter T Northcote, Jeremy G Owen
Metagenomic Exploration of the Marine Sponge Mycale hentscheli Uncovers Multiple Polyketide-Producing Bacterial Symbionts. mBio 11 (2) (2020)
Alistair S Brown, David F Ackerley, Mark J Calcott
High-Throughput Screening for Inhibitors of the SARS-CoV-2 Protease Using a FRET-Biosensor. Molecules (Basel, Switzerland) 25 (20) (2020)
Michelle H Rich, Abigail V Sharrock, Amir Ashoorzadeh, Adam V Patterson, Jeff B Smaill, David F Ackerley
Directed evolution of the B. subtilis nitroreductase YfkO improves activation of the PET-capable probe SN33623 and CB1954 prodrug. Biotechnology letters 43 (1) (2020)
Joe Bracegirdle, Luke P Robertson, Paul A Hume, Michael J Page, Abigail V Sharrock, David F Ackerley, Anthony R Carroll, Joanne E Harvey
Correction to Lamellarin Sulfates from the Pacific Tunicate Didemnum ternerratum. Journal of natural products 83 (10) (2020)
Jordan A J McCone, Kalpani K Somarathne, Christopher L Orme, Russell J Hewitt, Elysha-Rose Grant, Kelsi R Hall, David F Ackerley, Anne C La Flamme, Joanne E Harvey
Total Synthesis and Bioactivity Studies of Fungal Metabolite (-)-TAN-2483B. Organic letters 22 (24) (2020)
Kelsi R Hall, Katherine J Robins, Elsie M Williams, Michelle H Rich, Mark J Calcott, Janine N Copp, Rory F Little, Ralf Schwörer, Gary B Evans, Wayne M Patrick, David F Ackerley
Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active-site residues. eLife 9 (2020)
Elsie M Williams, Michelle H Rich, Alexandra M Mowday, Amir Ashoorzadeh, Janine N Copp, Christopher P Guise, Robert F Anderson, Jack U Flanagan, Jeff B Smaill, Adam V Patterson, David F Ackerley
Engineering Escherichia coli NfsB To Activate a Hypoxia-Resistant Analogue of the PET Probe EF5 To Enable Non-Invasive Imaging during Enzyme Prodrug Therapy. Biochemistry 58 (35) (2019)
Joe Bracegirdle, Luke P Robertson, Paul A Hume, Michael J Page, Abigail V Sharrock, David F Ackerley, Anthony R Carroll, Joanne E Harvey
Lamellarin Sulfates from the Pacific Tunicate Didemnum ternerratum. Journal of natural products 82 (7) (2019)
Luke J Stevenson, Jeremy G Owen, David F Ackerley
Metagenome Driven Discovery of Nonribosomal Peptides. ACS chemical biology 14 (10) (2019)
Elsie M Williams, Abigail V Sharrock, Elizabeth L Rylott, Neil C Bruce, Joanna K MacKichan, David F Ackerley
A cofactor consumption screen identifies promising NfsB family nitroreductases for dinitrotoluene remediation. Biotechnology letters 41 (10) (2019)
Benjaminas Valiauga, Lina Misevičienė, Michelle H Rich, David F Ackerley, Jonas Šarlauskas, Narimantas Čėnas
Mechanism of Two-/Four-Electron Reduction of Nitroaromatics by Oxygen-Insensitive Nitroreductases: The Role of a Non-Enzymatic Reduction Step. Molecules (Basel, Switzerland) 23 (7) (2018)
Mark J Calcott, Jeremy G Owen, Iain L Lamont, David F Ackerley
Biosynthesis of novel Pyoverdines by domain substitution in a nonribosomal peptide synthetase of Pseudomonas aeruginosa. Applied and environmental microbiology 80 (18) (2014)