Impact of large scale, multicomponent intervention to reduce proton pump inhibitor overuse in integrated healthcare system: difference-in-difference study.

Jacob E KurlanderLoren LaineHyungjin Myra KimChristopher B RobertsDarcy SaffarAimee MyersRobert HollemanYuqing GaoMichelle ShankRichard NelsonJane FormanChristian D HelfrichSarah L KreinSameer D SainiYu-Xiao Yang

Published in: BMJ (Clinical research ed.) (2024)

The multicomponent intervention was associated with reduced PPI use overall but also in patients appropriate for gastroprotection, with minimal evidence of either clinical benefits or harms.

Keyphrases

randomized controlled trial
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
small molecule
protein protein