Access to quinolinones via DMAP-catalysed cascade reaction of 2-substituted benzoic acids with organic azides.
Yuan-Yuan HeMei-Shan ZhuYang GaoXiao-Qiang HuPublished in: Chemical communications (Cambridge, England) (2022)
Herein, we report a DMAP-catalysed Curtius rearrangement and intramolecular cyclisation cascade reaction of 2-substituted aryl carboxylic acids with organic azides for the first time. This protocol features simple operation, broad scope and metal-free conditions, furnishing a broad spectrum of biologically attractive heterocycles. The synthetic virtue of this reaction was demonstrated by gram-scale synthesis and applicability toward drug-like molecules.