Mitochondrial Double-Stranded RNA in Exosome Promotes Interleukin-17 Production Through Toll-Like Receptor 3 in Alcohol-associated Liver Injury.
Jun-Hee LeeYoung-Ri ShimWonhyo SeoMyung-Ho KimWon-Mook ChoiHee-Hoon KimYe Eun KimKeungmo YangTom RyuJong-Min JeongHei-Gwon ChoiHyuk Soo EunSeok-Hwan KimHyejin MunJe-Hyun YoonWon-Il JeongPublished in: Hepatology (Baltimore, Md.) (2020)
EtOH-mediated generation of mtdsRNA contributes to TLR3 activation in Kupffer cells through exosomal delivery. Consequently, increased IL-1β expression in Kupffer cells triggers IL-17A production in γδ T cells at the early stage that may accelerate IL-17A expression in CD4+ T cells in the later stage of ALD. Therefore, mtdsRNA and TLR3 may function as therapeutic targets in ALD.
Keyphrases
- toll like receptor
- liver injury
- induced apoptosis
- inflammatory response
- early stage
- nuclear factor
- poor prognosis
- drug induced
- immune response
- cell cycle arrest
- oxidative stress
- binding protein
- endoplasmic reticulum stress
- signaling pathway
- squamous cell carcinoma
- long non coding rna
- sentinel lymph node
- alcohol consumption
- locally advanced