What is the role of CHCHD2 in adrenal tumourigenesis?

Angeliki KarapanagiotiNarjes Nasiri-AnsariAthanasios MoustogiannisGeorge C TrigasGeorgios ZografosChrysanthi AggeliGeorgios KyriakopoulosTheodosia ChoreftakiAnastassios PhilippouGregory KaltsasEva KassiAnna Angelousi

Published in: Endocrine (2023)

CHCHD2 expression seems to be implicated in adrenal tumourigenesis and its absence resulted to increased apoptosis in vitro. However, the exact mechanism of action and particularly its association with the BAX/BCL2 pathway needs to be further studied and evaluate whether it could be a protentional therapeutic target.

Keyphrases

poor prognosis
oxidative stress
endoplasmic reticulum stress

cell cycle arrest
cell death
induced apoptosis

density functional theory
long non coding rna

binding protein
pi k akt