Differential effects of radiation fractionation regimens on glioblastoma.
Kelly J McKelveyAmanda L HudsonHeather DonaghyShihani P StonerHelen R WheelerConnie I DiakosViive M HowellPublished in: Radiation oncology (London, England) (2022)
Spacing of hypofractionated RT doses 72 h apart showed increased median survival and tumor control via increased activation of RT-mediated cell death, with no observed increased in radiotoxicity. This supports further exploration of differential RT fractionated regimens in GB clinical trials to reduce delayed neurological radiotoxicity.