Intrahepatic IgA complex induces polarization of cancer-associated fibroblasts to matrix phenotypes in the tumor microenvironment of HCC.
Jong Geun ParkPu Reun RohMin Woo KangSung Woo ChoSuhyun HwangboHae Deok JungHyun Uk KimJi Hoon KimJae-Sung YooJi-Won HanJeong Won JangJong Young ChoiSeung Kew YoonYoung Kyoung YouHo Joong ChoiJae Yong RyuPil-Soo SungPublished in: Hepatology (Baltimore, Md.) (2024)
Intrahepatic IgA induced polarization of HCC-CAFs into more malignant matrix phenotypes and attenuates cytotoxic T-cell function. Our study highlighted their potential roles in tumor progression and immune suppression.
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