Intramyocardial Injection of Stem Cells in Pig Myocardial Infarction Model: The First Trial in Korea.
Min-Chul KimYong Sook KimWan Seok KangKi Hong LeeMeeyoung ChoMoon Hwa HongKyung Seob LimMyung Ho JeongYoungkeun AhnPublished in: Journal of Korean medical science (2018)
Although cell therapy is emerged for cardiac repair, its efficacy is modest by intracoronary infusion. Therefore, we established the intramyocardial delivery technique using a left ventricular (LV) mapping system (NOGA® XP) using 18 pigs. After adipose tissue-derived mesenchymal stem cells (ATSCs) were delivered intramyocardially to porcine infarcted heart, LV ejection fraction (EF) was increased, and LV chamber size was decreased. We proved the therapeutic effect of intramyocardial injection of ATSC through a LV mapping system in the porcine model for the first time in Korea. The adoption of this technique may accelerate the translation into a clinical application in the near future.
Keyphrases
- cell therapy
- left ventricular
- ejection fraction
- stem cells
- aortic stenosis
- adipose tissue
- heart failure
- high resolution
- mesenchymal stem cells
- hypertrophic cardiomyopathy
- left atrial
- high density
- ultrasound guided
- acute myocardial infarction
- cardiac resynchronization therapy
- low dose
- transcatheter aortic valve replacement
- study protocol
- mitral valve
- clinical trial
- current status
- high fat diet
- phase iii
- atrial fibrillation
- randomized controlled trial
- phase ii
- metabolic syndrome
- st elevation myocardial infarction
- acute coronary syndrome
- bone marrow