Pycnidiophorones A-D, four new cytochalasans from the wetland derived fungus Pycnidiophora dispersa .
Chen ZhaoGaoran LiuXingzhong LiuLan ZhangLin LiLing LiuPublished in: RSC advances (2020)
Pycnidiophorones A-D (1-4), four new cytochalasans with a rare 5/6/6/5/6 pentacyclic skeleton incorporating the unique 12-oxatricyclo[6.3.1.0 2,7 ]dodecane core, and six known depsidones (5-10) were isolated from cultures of the wetland-soil-derived fungus Pycnidiophora dispersa . Their chemical structures were unambiguously determined using NMR spectroscopic data. The absolute configurations of 1 and 3 were assigned by electronic circular dichroism (ECD) calculations. Compounds 1-10 showed moderate cytotoxicity against a panel of five human tumor cell lines.
Keyphrases
- wastewater treatment
- high resolution
- endothelial cells
- magnetic resonance
- molecular docking
- molecular dynamics
- density functional theory
- molecular dynamics simulations
- electronic health record
- induced pluripotent stem cells
- pluripotent stem cells
- water quality
- solid state
- mass spectrometry
- machine learning
- deep learning
- monte carlo