Aptamers Versus Vascular Endothelial Growth Factor (VEGF): A New Battle against Ovarian Cancer.
Yachana MishraAditi ChattarajVijay MishraAbhigyan RanjanMurtaza M TambuwalaPublished in: Pharmaceuticals (Basel, Switzerland) (2023)
Cancer is one of the diseases that causes a high mortality as it involves unregulated and abnormal cell growth proliferation that can manifest in any body region. One of the typical ovarian cancer symptoms is damage to the female reproductive system. The death rate can be reduced through early detection of the ovarian cancer. Promising probes that can detect ovarian cancer are suitable aptamers. Aptamers, i.e., so-called chemical antibodies, have a strong affinity for the target biomarker and can typically be identified starting from a random library of oligonucleotides. Compared with other probes, ovarian cancer targeting using aptamers has demonstrated superior detection effectiveness. Various aptamers have been selected to detect the ovarian tumor biomarker, vascular endothelial growth factor (VEGF). The present review highlights the development of particular aptamers that target VEGF and detect ovarian cancer at its earliest stages. The therapeutic efficacy of aptamers in ovarian cancer treatment is also discussed.
Keyphrases
- vascular endothelial growth factor
- nucleic acid
- endothelial cells
- small molecule
- randomized controlled trial
- type diabetes
- systematic review
- squamous cell carcinoma
- signaling pathway
- fluorescence imaging
- oxidative stress
- drug delivery
- young adults
- photodynamic therapy
- mass spectrometry
- quantum dots
- cardiovascular disease