Clinical Aspects of Janus Kinase (JAK) Inhibitors in the Cardiovascular System in Patients with Rheumatoid Arthritis.
Przemyslaw J KotylaMd Asiful IslamMałgorzata EngelmannPublished in: International journal of molecular sciences (2020)
Janus kinase (JAK) inhibitors, a novel class of targeted synthetic disease-modifying antirheumatic drugs (DMARDs), have shown their safety and efficacy in rheumatoid arthritis (RA) and are being intensively tested in other autoimmune and inflammatory disorders. Targeting several cytokines with a single small compound leads to blocking the physiological response of hundreds of genes, thereby providing the background to stabilize the immune response. Unfortunately, blocking many cytokines with a single drug may also bring some negative consequences. In this review, we focused on the activity of JAK inhibitors in the cardiovascular system of patients with RA. Special emphasis was put on the modification of heart performance, progression of atherosclerosis, lipid profile disturbance, and risk of thromboembolic complications. We also discussed potential pathophysiological mechanisms that may be responsible for such JAK inhibitor-associated side effects.
Keyphrases
- rheumatoid arthritis
- disease activity
- immune response
- rheumatoid arthritis patients
- ankylosing spondylitis
- interstitial lung disease
- atrial fibrillation
- cardiovascular disease
- multiple sclerosis
- systemic lupus erythematosus
- tyrosine kinase
- heart failure
- drug induced
- genome wide
- risk factors
- type diabetes
- gene expression
- inflammatory response
- risk assessment
- toll like receptor
- transcription factor
- climate change
- human health
- genome wide identification