APC gene is modulated by hsa-miR-135b-5p in both diffuse and intestinal gastric cancer subtypes.
Leandro MagalhãesLuciana Gonçalves QuintanaDielly Catrina Favacho LopesAmanda Ferreira VidalAdenilson Leão PereiraLara Carolina D'Araujo PintoJoão de Jesus Viana PinheiroAndré Salim KhayatLuiz Ricardo GoulartRommel BurbanoPaulo Pimentel de AssumpçãoÂndrea Kely Campos Ribeiro Dos SantosPublished in: BMC cancer (2018)
We concluded that three-dimensional culture can be a more representative in vitro model that resembles better the in vivo reality. Our results also showed that hsa-miR-29c-5p is an important regulator of CDC42 and DNMT3A genes in the intestinal subtype gastric cancer and hsa-miR-135b-5p regulates the APC gene in both intestinal and diffuse subtypes of GC. Dysregulation in their expression, and consequently in their respectively signaling pathways, shows how these miRNAs can influence the carcinogenesis of different histological subtypes of gastric cancer.