Accuracy of HPV E6/E7 oncoprotein tests to detect high-grade cervical lesions: a systematic literature review and meta-analysis.
Laura DownhamIman JaafarMary Luz RolVictoria Nyawira NyagaJoan VallsArmando BaenaLi ZhangMarc J GunterMarc ArbynMaribel AlmontePublished in: British journal of cancer (2023)
The high specificity of oncoprotein tests supports its use for triaging HPV-positive women. However, oncoprotein-negative women would not be recommended to undertake routine screening, requiring further follow-up. Large-scale and longitudinal studies are needed to further investigate the role of E6/E7-oncoprotein detection in predicting the risk of developing cervical pre-cancer and cancer.
Keyphrases
- high grade
- papillary thyroid
- cervical cancer screening
- polycystic ovary syndrome
- low grade
- squamous cell
- pregnancy outcomes
- lymph node metastasis
- type diabetes
- squamous cell carcinoma
- cross sectional
- clinical practice
- insulin resistance
- metabolic syndrome
- pregnant women
- childhood cancer
- young adults
- skeletal muscle
- structural basis
- sensitive detection