Impact of CYP genotype and inflammatory markers on the plasma concentrations of tramadol and its demethylated metabolites and drug tolerability in cancer patients.

Hironari TanakaTakafumi NaitoHikaru SatoTakanori HiraideYasuhide YamadaJunichi Kawakami

Published in: European journal of clinical pharmacology (2018)

The CYP2D6 genotype but not the CYP2B6 and CYP3A5 genotypes affected the plasma concentrations of O- and N-desmethyltramadol through alteration of the tramadol metabolic pathway. The serum IL-6 level was associated with N-demethylation activity and tramadol tolerability.

Keyphrases

open label
ms ms
double blind
randomized controlled trial
emergency department
study protocol